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<p>One of the biggest challenges in phage therapy is selecting the ‘right’ phage. What constitutes a ‘good’ phage is unclear, but regulators are converging on exclusion criteria for ‘bad’ phages. Here, we examine three commonly applied criteria: the lack of virulence/antibiotic resistance, the inability to transduce, and being strictly lytic (virulent). We assess the risk posed, the tools for determining the criteria, and the potential impact of the criteria.</p>

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Re-evaluating what makes a phage unsuitable for therapy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月29日

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  • Bradley W. M. Cook,
  • Alexander P. Hynes

摘要

One of the biggest challenges in phage therapy is selecting the ‘right’ phage. What constitutes a ‘good’ phage is unclear, but regulators are converging on exclusion criteria for ‘bad’ phages. Here, we examine three commonly applied criteria: the lack of virulence/antibiotic resistance, the inability to transduce, and being strictly lytic (virulent). We assess the risk posed, the tools for determining the criteria, and the potential impact of the criteria.