Scholarlink

<p>The multiply antibiotic-resistant lineage 1 of <i>Acinetobacter baumannii</i> global clone 1 (GC1) emerged in the 1970s, and subsequently more extensively resistant sublineages have emerged. Here, we examined the evolution of the extensively resistant MRSN56 sublineage and showed it is characterised by insertions carrying resistance genes at specific chromosomal positions. An evolved form of the sublineage carries KL17 replacing KL1 at the capsule locus and includes an additional integrative element Aci-IE1 carrying further resistance genes including <i>bla</i><sub>NDM</sub>. Further members of the modified sublineage (isolated 2014–2021) identified among publicly available genomes were from several countries and appear to have replaced the original form (2007–2010). Some KL17 type isolates had acquired even more resistance genes including <i>bla</i><sub>PER</sub>. The <i>bla</i><sub>NDM</sub> and <i>bla</i><sub>PER</sub> genes contribute to reduced susceptibility to cefiderocol and/or sulbactam/durlobactam. The phylogeny indicated that separation of the sublineage into KL1 and KL17 groups coincided with the KL switch and Aci-IE1 was acquired later.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evolution of an extensively antibiotic resistant sublineage of lineage 1 of GC1 Acinetobacter baumannii

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月9日

查看全文
  • Christopher J. Harmer,
  • Ting L. Luo,
  • Francois Lebreton,
  • Patrick T. McGann,
  • Ruth M. Hall

摘要

The multiply antibiotic-resistant lineage 1 of Acinetobacter baumannii global clone 1 (GC1) emerged in the 1970s, and subsequently more extensively resistant sublineages have emerged. Here, we examined the evolution of the extensively resistant MRSN56 sublineage and showed it is characterised by insertions carrying resistance genes at specific chromosomal positions. An evolved form of the sublineage carries KL17 replacing KL1 at the capsule locus and includes an additional integrative element Aci-IE1 carrying further resistance genes including blaNDM. Further members of the modified sublineage (isolated 2014–2021) identified among publicly available genomes were from several countries and appear to have replaced the original form (2007–2010). Some KL17 type isolates had acquired even more resistance genes including blaPER. The blaNDM and blaPER genes contribute to reduced susceptibility to cefiderocol and/or sulbactam/durlobactam. The phylogeny indicated that separation of the sublineage into KL1 and KL17 groups coincided with the KL switch and Aci-IE1 was acquired later.