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<p>Since its discovery nearly 60 years ago, TolC has been associated with various cellular functions in <i>Escherichia coli</i>, including the efflux of environmental stressors and virulence factors. It also acts as a receptor for specific bacteriophages and the colicin E1 toxin. This review highlights key discoveries over the past six decades and emphasizes the remaining gaps in understanding how TolC contributes to physiological functions in <i>E. coli</i>.</p>

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A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年1月25日

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  • Mallory Wright,
  • Mandeep Kaur,
  • Laura K. Thompson,
  • Georgina Cox

摘要

Since its discovery nearly 60 years ago, TolC has been associated with various cellular functions in Escherichia coli, including the efflux of environmental stressors and virulence factors. It also acts as a receptor for specific bacteriophages and the colicin E1 toxin. This review highlights key discoveries over the past six decades and emphasizes the remaining gaps in understanding how TolC contributes to physiological functions in E. coli.