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Narrative review of recent developments and the future of penicillin allergy de-labelling by non-allergists

  • Neil Powell,
  • Michael Blank,
  • Akish Luintel,
  • Shuayb Elkhalifa,
  • Rashmeet Bhogal,
  • Michael Wilcock,
  • Michael Wakefield,
  • Jonathan Sandoe

摘要

This article outlines recent developments in non-allergist delivered penicillin allergy de-labelling (PADL), discusses remaining controversies and uncertainties and explores the future for non-allergist delivered PADL. Recent developments include national guidelines for non-allergist delivered PADL and validation of penicillin allergy risk assessment tools. Controversies remain on which penicillin allergy features are low risk of genuine allergy. In the future genetic or immunological tests may facilitate PADL.