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<p>Cell-based immunotherapy has emerged as a promising strategy for a wide range of diseases, including cancer, autoimmune disorders and infectious diseases. Two major approaches are currently being pursued, including generating therapeutic cells from autologous or allogeneic peripheral blood mononuclear cells and differentiating these cells from stem cells such as haematopoietic stem cells or pluripotent stem cells. Advances in stem cell gene engineering and differentiation platforms have enabled the generation of therapeutic immune cells, including T cells, natural killer cells, macrophages and chimeric antigen receptor-engineered counterparts, with clinically compatible manufacturing processes, potent anti-disease efficacy, enhanced safety and reduced immunogenicity. In this Review, we discuss key developments in stem cell engineering, focusing on genetic modifications that enhance therapeutic cell functionality, safety and immune tolerance, as well as advances in stem cell differentiation platforms and emerging clinical evidence.</p>

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Allogeneic immunotherapy

  • 期刊论文

  • 发表日期：

    2026年8月5日

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  • Yan-Ruide Li,
  • Yichen Zhu,
  • Xinyuan Shen,
  • Yuning Chen,
  • Lili Yang

摘要

Cell-based immunotherapy has emerged as a promising strategy for a wide range of diseases, including cancer, autoimmune disorders and infectious diseases. Two major approaches are currently being pursued, including generating therapeutic cells from autologous or allogeneic peripheral blood mononuclear cells and differentiating these cells from stem cells such as haematopoietic stem cells or pluripotent stem cells. Advances in stem cell gene engineering and differentiation platforms have enabled the generation of therapeutic immune cells, including T cells, natural killer cells, macrophages and chimeric antigen receptor-engineered counterparts, with clinically compatible manufacturing processes, potent anti-disease efficacy, enhanced safety and reduced immunogenicity. In this Review, we discuss key developments in stem cell engineering, focusing on genetic modifications that enhance therapeutic cell functionality, safety and immune tolerance, as well as advances in stem cell differentiation platforms and emerging clinical evidence.