Scholarlink

<p>Hyaluronic acid (HyA), also known as hyaluronan or hyaluronate in its salt form, is a linear glycosaminoglycan biopolymer that has been used in therapeutics and biomaterials engineering owing to its abundant distribution in biological tissues and diverse roles in biological processes. The well-established biocompatibility of HyA has facilitated its adoption in numerous medical devices, particularly in reconstructive surgery and tissue regeneration applications. The interactions of HyA with cells and their respective surface receptors across tissues throughout the body mediate the effects of the former in the context of development, wound healing, tissue repair and regeneration. In this Review, we address the impact of HyA on tissue regeneration and discuss muscle injuries as an example in which strategies for HyA-based products could enhance muscle’s intrinsic regenerative capabilities. Finally, we consider the evolving regulatory oversight of HyA-based products by the Food and Drug Administration in the context of the roles of HyA in biological processes to understand these products’ putative modes of action. Deeper understanding of the mechanism of action of HyA in the body can inform the regulatory classification of future HyA-based products.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Interaction-driven classification of hyaluronic acid products

  • 期刊论文

  • 发表日期：

    2025年12月8日

查看全文
  • Ryan Granché,
  • Kavita Parekh,
  • Ehsan Farjood,
  • Sydney Shriver,
  • Richard McFarland,
  • Howard Ying,
  • Manasi Kumar,
  • Pranav Addepalli,
  • George J. Christ,
  • Kevin E. Healy

摘要

Hyaluronic acid (HyA), also known as hyaluronan or hyaluronate in its salt form, is a linear glycosaminoglycan biopolymer that has been used in therapeutics and biomaterials engineering owing to its abundant distribution in biological tissues and diverse roles in biological processes. The well-established biocompatibility of HyA has facilitated its adoption in numerous medical devices, particularly in reconstructive surgery and tissue regeneration applications. The interactions of HyA with cells and their respective surface receptors across tissues throughout the body mediate the effects of the former in the context of development, wound healing, tissue repair and regeneration. In this Review, we address the impact of HyA on tissue regeneration and discuss muscle injuries as an example in which strategies for HyA-based products could enhance muscle’s intrinsic regenerative capabilities. Finally, we consider the evolving regulatory oversight of HyA-based products by the Food and Drug Administration in the context of the roles of HyA in biological processes to understand these products’ putative modes of action. Deeper understanding of the mechanism of action of HyA in the body can inform the regulatory classification of future HyA-based products.