<p>Agroecological droughts are expected to increase with climate change, becoming one of the greatest threats to ecosystems and human society. To mitigate climate change and the growing risk of agroecological droughts, carbon dioxide removal (CDR) is increasingly recognized as unavoidable. However, it remains unclear whether the increase of agroecological drought due to atmospheric CO₂ emissions will be symmetrically reversed by an equivalent atmospheric CDR. Here we investigate this question by utilizing an idealized atmospheric CO₂ emission and removal experiment from the CDR Model Intercomparison Project, involving eight Earth system models, and develop a new methodology to quantify climate hysteresis and reversibility. We find that drought increases in hotspot regions cannot be symmetrically reversed by an equivalent CDR: drought severity under the CDR pathway is 65% ± 30% greater than under the emission pathway; drought frequency increases are only partially reversed by 73% ± 18% when CO₂ emissions are balanced by equivalent CDR. Drought hysteresis and irreversibility are most pronounced in the Mediterranean, northern Central America, west and east southern Africa and southern Australia. Our findings imply irreversible drought impacts associated with CDR, highlighting the need for planning long-term drought adaptations.</p>