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<p>Face perception is essential for social interaction, but its neural basis and development in autism remain unclear. Using multivariate pattern analysis on high-density electroencephalography data from a large pediatric case–control observational study (<i>N</i> = 399), we found that autistic children exhibited less distinct face- and identity-selective neural representations than neurotypical (NT) children. During specific stages of face processing, the neural representations for faces, inverted faces and houses were significantly more distinct in NT compared with autistic children. Across developmental age groups (6–7-, 8–9- and 10–11-year-olds), NT children showed increasing neural specialization across age such that face- and identity-selective neural representations became more distinct across age, a pattern not observed in autistic children. These findings provide insight into the neural processes underlying face perception differences in autism and underscore the importance of understanding developmental trajectories of face-selective neural representations.</p>

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Decoding the temporal dynamics of face-specific neural representations in autism

  • 期刊论文

  • 发表日期：

    2026年6月29日

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  • Jason W. Griffin,
  • Alan H. Gerber,
  • Kaylee Litson,
  • Susan Faja,
  • Shafali Jeste,
  • Natalia Kleinhans,
  • Geraldine Dawson,
  • Adam Naples,
  • April R. Levin,
  • Sara Jane Webb,
  • Frederick Shic,
  • Catherine Sugar,
  • James Dziura,
  • James C. McPartland

摘要

Face perception is essential for social interaction, but its neural basis and development in autism remain unclear. Using multivariate pattern analysis on high-density electroencephalography data from a large pediatric case–control observational study (N = 399), we found that autistic children exhibited less distinct face- and identity-selective neural representations than neurotypical (NT) children. During specific stages of face processing, the neural representations for faces, inverted faces and houses were significantly more distinct in NT compared with autistic children. Across developmental age groups (6–7-, 8–9- and 10–11-year-olds), NT children showed increasing neural specialization across age such that face- and identity-selective neural representations became more distinct across age, a pattern not observed in autistic children. These findings provide insight into the neural processes underlying face perception differences in autism and underscore the importance of understanding developmental trajectories of face-selective neural representations.