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<p>The causal link between potentially traumatic events and obsessive–compulsive disorder (OCD) remains unclear due to reliance on retrospective self-reports and limited control for familial factors. Here, in this Swedish population-based cohort study, we identified 3,340,945 individuals born between 1975 and 2008 and prospectively examined the associations of objectively recorded assault/victimization and transport accidents with subsequent OCD diagnoses. Individuals exposed to assault/victimization, but not transport accidents, had an increased OCD risk (hazard ratio (HR) 1.73, 95% confidence interval (CI) 1.63–1.83), especially within the first year (HR 2.31, 95% CI 1.98–2.70), decreasing thereafter (HR 1.67, 95% CI 1.57–1.77). The association persisted in discordant full sibling comparisons (HR 1.37, 95% CI 1.23–1.54). Quantitative genetic modeling indicated that the phenotypic correlation (<i>r</i> = 0.12) was primarily due to additive genetic (69%) and unique environmental factors (31%). These findings highlight a complex relationship between assault/victimization and OCD, involving both genetic vulnerability and individual environmental exposure.</p>

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Short- and long-term incidence of obsessive–compulsive disorder after objectively recorded potentially traumatic events

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月9日

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  • Josep Pol-Fuster,
  • Lorena Fernández de la Cruz,
  • Ralf Kuja-Halkola,
  • Elles de Schipper,
  • Paul Lichtenstein,
  • Zheng Chang,
  • Isabell Brikell,
  • Brian M. D’Onofrio,
  • Henrik Larsson,
  • Christian Rück,
  • Gustaf Brander,
  • Jan C. Beucke,
  • Unnur A. Valdimarsdóttir,
  • David Mataix-Cols

摘要

The causal link between potentially traumatic events and obsessive–compulsive disorder (OCD) remains unclear due to reliance on retrospective self-reports and limited control for familial factors. Here, in this Swedish population-based cohort study, we identified 3,340,945 individuals born between 1975 and 2008 and prospectively examined the associations of objectively recorded assault/victimization and transport accidents with subsequent OCD diagnoses. Individuals exposed to assault/victimization, but not transport accidents, had an increased OCD risk (hazard ratio (HR) 1.73, 95% confidence interval (CI) 1.63–1.83), especially within the first year (HR 2.31, 95% CI 1.98–2.70), decreasing thereafter (HR 1.67, 95% CI 1.57–1.77). The association persisted in discordant full sibling comparisons (HR 1.37, 95% CI 1.23–1.54). Quantitative genetic modeling indicated that the phenotypic correlation (r = 0.12) was primarily due to additive genetic (69%) and unique environmental factors (31%). These findings highlight a complex relationship between assault/victimization and OCD, involving both genetic vulnerability and individual environmental exposure.