Scholarlink

<p>Depressive and anxiety disorders are characterized by altered connectivity within and between the default mode network (DMN) and salience network. Basal forebrain subdivisions, critical for regulating network activity, remain understudied across these conditions. To address this gap, we analyzed 7-Tesla resting-state functional magnetic resonance imaging data from a transdiagnostic sample (<i>n</i> = 70), primarily with depressive and anxiety disorders, and healthy controls (<i>n</i> = 77). We used spectral dynamic causal modeling to assess effective connectivity between the medial septum/diagonal band (Ch1–3), nucleus basalis of Meynert (Ch4), ventral pallidum, and DMN and salience network. Healthy participants showed excitatory connectivity from Ch1–3 to the DMN and from Ch4 to the anterior insula. By contrast, clinical participants exhibited greater inhibitory Ch4 to DMN connectivity and increased excitatory connectivity from Ch4 to the anterior insula. Widespread Ch4 connectivity dysfunction may implicate the cholinergic system as a mechanistic and therapeutic target for depressive and anxiety disorders.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Altered basal forebrain regulation of intrinsic brain networks in depressive and anxiety disorders

  • 期刊论文

  • 发表日期：

    2025年9月8日

查看全文
  • Alec J. Jamieson,
  • Trevor Steward,
  • Christopher G. Davey,
  • Sevil Ince,
  • James A. Agathos,
  • Bradford A. Moffat,
  • Rebecca K. Glarin,
  • Kim L. Felmingham,
  • Ben J. Harrison

摘要

Depressive and anxiety disorders are characterized by altered connectivity within and between the default mode network (DMN) and salience network. Basal forebrain subdivisions, critical for regulating network activity, remain understudied across these conditions. To address this gap, we analyzed 7-Tesla resting-state functional magnetic resonance imaging data from a transdiagnostic sample (n = 70), primarily with depressive and anxiety disorders, and healthy controls (n = 77). We used spectral dynamic causal modeling to assess effective connectivity between the medial septum/diagonal band (Ch1–3), nucleus basalis of Meynert (Ch4), ventral pallidum, and DMN and salience network. Healthy participants showed excitatory connectivity from Ch1–3 to the DMN and from Ch4 to the anterior insula. By contrast, clinical participants exhibited greater inhibitory Ch4 to DMN connectivity and increased excitatory connectivity from Ch4 to the anterior insula. Widespread Ch4 connectivity dysfunction may implicate the cholinergic system as a mechanistic and therapeutic target for depressive and anxiety disorders.