Scholarlink

<p>Historically, aperiodic neural activity (the 1/<i>f</i> exponent and offset of electroencephalogram power spectra) has been treated as neural noise. However, recent work has highlighted associations among aperiodic activity, aging, cognition and psychopathology. Although depression has been associated with cognitive deficits and dysregulation of excitatory–inhibitory neural mechanisms linked to aperiodic activity, so far, few studies have compared aperiodic activity in adults with and without depression, and none have evaluated aperiodic activity as a function of depressive chronicity. Here individuals with depression (<i>n</i> = 72) and healthy controls (<i>n</i> = 34) completed a resting state electroencephalography recording from which aperiodic activity estimates were extracted. We show significant group differences in aperiodic exponent and offset across central and posterior regions, such that, as hypothesized, these parameters were lower for depressed individuals relative to controls. Follow-up analyses clarified that this effect was driven by the number of lifetime depressive episodes experienced. Future research is needed to understand how depression heterogeneity impacts aperiodic activity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Alterations in aperiodic neural activity associated with major depressive disorder

  • 期刊论文

  • 发表日期：

    2025年9月4日

查看全文
  • Sarah E. Woronko,
  • Mohan Li,
  • Jason N. Scott Jr,
  • Manuel Kuhn,
  • Shiba M. Esfand,
  • Mario Bogdanov,
  • Brian W. Boyle,
  • Samantha R. Linton,
  • Lauren R. Borchers,
  • Peter Zhukovsky,
  • Courtney Miller,
  • Paula Bolton,
  • Shuang Li,
  • Robert C. Meisner,
  • Ty Lees,
  • Diego A. Pizzagalli

摘要

Historically, aperiodic neural activity (the 1/f exponent and offset of electroencephalogram power spectra) has been treated as neural noise. However, recent work has highlighted associations among aperiodic activity, aging, cognition and psychopathology. Although depression has been associated with cognitive deficits and dysregulation of excitatory–inhibitory neural mechanisms linked to aperiodic activity, so far, few studies have compared aperiodic activity in adults with and without depression, and none have evaluated aperiodic activity as a function of depressive chronicity. Here individuals with depression (n = 72) and healthy controls (n = 34) completed a resting state electroencephalography recording from which aperiodic activity estimates were extracted. We show significant group differences in aperiodic exponent and offset across central and posterior regions, such that, as hypothesized, these parameters were lower for depressed individuals relative to controls. Follow-up analyses clarified that this effect was driven by the number of lifetime depressive episodes experienced. Future research is needed to understand how depression heterogeneity impacts aperiodic activity.