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<p>Visceral rhythms orchestrate the physiological states underlying human emotion. Chronic aberrations in these brain–body interactions are implicated in a broad spectrum of mental health disorders. However, the relationship between gastric–brain coupling and affective symptoms remains poorly understood. Here we investigated the relationship between this novel interoceptive axis and mental health in 243 participants, using a cross-validated machine learning approach. We find that increased frontoparietal brain coupling to the gastric rhythm indexes a dimensional signature of poorer mental health, spanning anxiety, depression, stress and well-being. Control analyses confirm the specificity of these interactions to the gastric–brain axis. Our study proposes coupling between the stomach and brain as a factor in mental health and offers potential new targets for interventions remediating aberrant brain–body coupling.</p>

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Stomach–brain coupling indexes a dimensional signature of mental health

  • 期刊论文

  • 发表日期：

    2025年7月30日

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  • Leah Banellis,
  • Ignacio Rebollo,
  • Niia Nikolova,
  • Micah Allen

摘要

Visceral rhythms orchestrate the physiological states underlying human emotion. Chronic aberrations in these brain–body interactions are implicated in a broad spectrum of mental health disorders. However, the relationship between gastric–brain coupling and affective symptoms remains poorly understood. Here we investigated the relationship between this novel interoceptive axis and mental health in 243 participants, using a cross-validated machine learning approach. We find that increased frontoparietal brain coupling to the gastric rhythm indexes a dimensional signature of poorer mental health, spanning anxiety, depression, stress and well-being. Control analyses confirm the specificity of these interactions to the gastric–brain axis. Our study proposes coupling between the stomach and brain as a factor in mental health and offers potential new targets for interventions remediating aberrant brain–body coupling.