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<p>Brain function is critically dependent on energy metabolism. Research over the past half century has provided many insights into energy production and utilization in the brain, and identified ways that it can be improved in brain disorders. A parallel literature indicates that major aberrations exist in brain bioenergetics in neuropsychiatric disorders. Targeting bioenergetic abnormalities may be an efficacious approach to treatment for these conditions. In this Perspective, we provide a survey of the relevant literature on these topics and sketch the outlines of a research agenda to maximize the impact of future research and treatment interventions.</p>

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Brain and body energy metabolism and potential for treatment of psychiatric disorders

  • 期刊论文

  • 发表日期：

    2025年6月25日

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  • Ana C. Andreazza,
  • L. Felipe Barros,
  • Alexander Behnke,
  • Dorit Ben-Shachar,
  • Sabina Berretta,
  • Virginie-Anne Chouinard,
  • Kim Do,
  • Sharmili Edwin Thanarajah,
  • Hannelore Ehrenreich,
  • Peter Falkai,
  • Judith Ford,
  • Zachary Freyberg,
  • Javier Gilbert-Jaramillo,
  • Jill R. Glausier,
  • Manu S. Goyal,
  • Margaret Hahn,
  • Suzana Herculano-Houzel,
  • David Hofmann,
  • Iris-Tatjana Kolassa,
  • Matthias Mack,
  • R. Nehir Mavioglu,
  • Robert McCullumsmith,
  • Yuri Milaneschi,
  • Anthony J. A. Molina,
  • Lilianne Mujica-Parodi,
  • Dost Öngür,
  • Martin Paulus,
  • Daria Peleg-Raibstein,
  • Ben Perry,
  • Martin Picard,
  • Toby Pillinger,
  • Caroline Rae,
  • Douglas Rothman,
  • Zoltan Sarnyai,
  • Johann Steiner,
  • Rachel Upthegrove,
  • Anthony C. Vernon,
  • Melanie Wall,
  • Corey Weistuch

摘要

Brain function is critically dependent on energy metabolism. Research over the past half century has provided many insights into energy production and utilization in the brain, and identified ways that it can be improved in brain disorders. A parallel literature indicates that major aberrations exist in brain bioenergetics in neuropsychiatric disorders. Targeting bioenergetic abnormalities may be an efficacious approach to treatment for these conditions. In this Perspective, we provide a survey of the relevant literature on these topics and sketch the outlines of a research agenda to maximize the impact of future research and treatment interventions.