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<p>Many biological tissues contain colloids within a fibrillar structure. Here, we develop and characterize colloidal-fibrillar scaffolds through examination of the effects of relative colloid and fiber ratios within a fibrin-based model system composed of fibrin-based nanoparticles (FBNs) within a natural fibrin scaffold. At lower concentrations, FBNs primarily integrate into the fibrillar fibrin matrix, strengthening it. At high concentrations, colloid-colloid interactions dominate and FBNs primarily form a highly aligned secondary structure that does not strengthen the fibrillar matrix. At intermediate concentrations, both reinforcement of the fibrin matrix and colloid-colloid interactions are observed. Our characterization of this colloidal-fibrillar system provides insight into new avenues for wound healing biomaterial development. Using structural and mechanical results, we developed a biomimetic surgical sealant. When applied to a vascular healing model, FBN gel resulted in improved vessel healing. This colloidal-fibrillar composite can greatly improve healing outcomes and should be applied to other tissues.</p>

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Colloidal-fibrillar composite gels demonstrate structural reinforcement, secondary fibrillar alignment, and improved vascular healing outcomes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月8日

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  • Nina A. Moiseiwitsch,
  • Sanika Pandit,
  • Nicole Zwennes,
  • Kimberly Nellenbach,
  • Ana Sheridan,
  • Jessica LeGrand,
  • Eunice Chee,
  • Sarah Ozawa,
  • Brigid Troan,
  • Wen Yih Aw,
  • William Polacheck,
  • Mansoor A. Haider,
  • Ashley C. Brown

摘要

Many biological tissues contain colloids within a fibrillar structure. Here, we develop and characterize colloidal-fibrillar scaffolds through examination of the effects of relative colloid and fiber ratios within a fibrin-based model system composed of fibrin-based nanoparticles (FBNs) within a natural fibrin scaffold. At lower concentrations, FBNs primarily integrate into the fibrillar fibrin matrix, strengthening it. At high concentrations, colloid-colloid interactions dominate and FBNs primarily form a highly aligned secondary structure that does not strengthen the fibrillar matrix. At intermediate concentrations, both reinforcement of the fibrin matrix and colloid-colloid interactions are observed. Our characterization of this colloidal-fibrillar system provides insight into new avenues for wound healing biomaterial development. Using structural and mechanical results, we developed a biomimetic surgical sealant. When applied to a vascular healing model, FBN gel resulted in improved vessel healing. This colloidal-fibrillar composite can greatly improve healing outcomes and should be applied to other tissues.