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<p>Widely used in millions of atherosclerosis treatments, conventional metal stents, although pervasive, only provide mechanical support to narrowed arteries. However, many patients experience in-stent restenosis after implantation. Here we developed smart magnetoelastic stents that preserve mechanical functionality while enabling self-powered hemodynamic monitoring for continuous and timely diagnosis of in-stent restenosis. Using a clinical catheter, the smart stent is deployed in the swine carotid artery for in vivo hemodynamic sensing, enabling effective detection of induced stenosis through artificial intelligence-assisted signal interpretation. In vivo and in vitro studies demonstrate the biosafety of the smart stent through immune profiling, human cytokine analysis and single-cell RNA sequencing. These results underscore the smart stent’s potential for seamless integration into biological systems as a reliable diagnostic tool. This platform technology could potentially revolutionize current stent technology and contribute to improved strategies for managing atherosclerosis.</p>

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Self-powered in-stent restenosis diagnosis via magnetoelastic stents

  • 期刊论文

  • 发表日期：

    2026年2月16日

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  • Guorui Chen,
  • Wi Jin Kim,
  • Youcheng Yang,
  • Yan-Ruide Li,
  • Jing Tian,
  • Junkai Zhang,
  • Xun Zhao,
  • Kamryn Scott,
  • Lily G. Defelice,
  • Zeyang Liu,
  • Jing Xu,
  • Tzuchun Chung,
  • Jarod Carol,
  • Yihao Zhou,
  • Anthony C. Wang,
  • Olujimi A. Ajijola,
  • Paul S. Weiss,
  • Wei Wang,
  • Song Li,
  • Geoffrey P. Colby,
  • Jun Chen

摘要

Widely used in millions of atherosclerosis treatments, conventional metal stents, although pervasive, only provide mechanical support to narrowed arteries. However, many patients experience in-stent restenosis after implantation. Here we developed smart magnetoelastic stents that preserve mechanical functionality while enabling self-powered hemodynamic monitoring for continuous and timely diagnosis of in-stent restenosis. Using a clinical catheter, the smart stent is deployed in the swine carotid artery for in vivo hemodynamic sensing, enabling effective detection of induced stenosis through artificial intelligence-assisted signal interpretation. In vivo and in vitro studies demonstrate the biosafety of the smart stent through immune profiling, human cytokine analysis and single-cell RNA sequencing. These results underscore the smart stent’s potential for seamless integration into biological systems as a reliable diagnostic tool. This platform technology could potentially revolutionize current stent technology and contribute to improved strategies for managing atherosclerosis.