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<p>The small size of nanoparticles complicates surface adsorption studies, and their unclear structure limits the accuracy of traditional analytical methods. Nanoclusters, with precise structures, offer a molecular-level approach for studying surface adsorption phenomena. Here we used flexible, sterically hindered probenecid ligands to mimic surfactants in classic micelle structures and developed a co-encapsulation strategy to synthesize spherical aluminium oxo clusters (<b>SAlOC-1</b>). The spherical surface of <b>SAlOC-1</b> maximally exposes supramolecular sites and provides a guest-accessible environment. <b>SAlOC-1</b> can accommodate up to 20 different drug-related guests across a wide range of sizes at room temperature via a single-crystal-to-single-crystal transformation. These results highlight <b>SAlOC-1</b>’s advantages in guest determination, including the ability to overcome limitations associated with liquid-phase host–guest chemistry in traditional discrete systems, ease of operation, the coexistence of universality and selectivity, and biomimetic multicomponent binding. Theoretical studies reveal that <b>SAlOC-1</b>’s recognition mechanism differs from that of porous framework materials, relying instead on ligand flexibility to form a half-open-door configuration, acting as a molecular catcher.</p><p></p>

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Precise synthesis of spherical aluminium oxo clusters for accurate surface guest recognition

  • 期刊论文

  • 发表日期：

    2025年11月27日

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  • Si-Hao Shen,
  • Jian Hao,
  • Minyi Zhang,
  • Ying-Hua Yu,
  • Jian-Bing Chen,
  • Dominic Wright,
  • Chunsen Li,
  • Wei-Hui Fang,
  • Jian Zhang

摘要

The small size of nanoparticles complicates surface adsorption studies, and their unclear structure limits the accuracy of traditional analytical methods. Nanoclusters, with precise structures, offer a molecular-level approach for studying surface adsorption phenomena. Here we used flexible, sterically hindered probenecid ligands to mimic surfactants in classic micelle structures and developed a co-encapsulation strategy to synthesize spherical aluminium oxo clusters (SAlOC-1). The spherical surface of SAlOC-1 maximally exposes supramolecular sites and provides a guest-accessible environment. SAlOC-1 can accommodate up to 20 different drug-related guests across a wide range of sizes at room temperature via a single-crystal-to-single-crystal transformation. These results highlight SAlOC-1’s advantages in guest determination, including the ability to overcome limitations associated with liquid-phase host–guest chemistry in traditional discrete systems, ease of operation, the coexistence of universality and selectivity, and biomimetic multicomponent binding. Theoretical studies reveal that SAlOC-1’s recognition mechanism differs from that of porous framework materials, relying instead on ligand flexibility to form a half-open-door configuration, acting as a molecular catcher.