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<p>Functional neurological disorder (FND) and posttraumatic stress disorder (PTSD) show considerable psychological and neurobiological parallels despite distinct clinical presentations. In this Perspective, we synthesize emerging research on shared disruptions in emotion processing and regulation, interoceptive processing, self-appraisal and dissociation, physiological stress responses and fear-extinction learning. From these commonalities, we propose a transdiagnostic mechanism-focused approach to FND treatment, drawing on the evidence base for PTSD interventions. Specifically, we examine the potential of prolonged exposure therapy and the unified protocol for transdiagnostic treatment of emotional disorders to address FND symptoms, particularly in people with emotion-regulation difficulties and&#xa0;histories of histories. Although rigorous empirical validation is needed, bridging neuroscientific insights with clinical practice should open up avenues for research and intervention in complex neuropsychiatric features in people with FND.</p>

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How insights from posttraumatic stress disorder can inform treatment of functional neurological disorder

  • 期刊论文

  • 发表日期：

    2025年7月24日

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  • Andrea Putica,
  • James Agathos,
  • Kim Felmingham

摘要

Functional neurological disorder (FND) and posttraumatic stress disorder (PTSD) show considerable psychological and neurobiological parallels despite distinct clinical presentations. In this Perspective, we synthesize emerging research on shared disruptions in emotion processing and regulation, interoceptive processing, self-appraisal and dissociation, physiological stress responses and fear-extinction learning. From these commonalities, we propose a transdiagnostic mechanism-focused approach to FND treatment, drawing on the evidence base for PTSD interventions. Specifically, we examine the potential of prolonged exposure therapy and the unified protocol for transdiagnostic treatment of emotional disorders to address FND symptoms, particularly in people with emotion-regulation difficulties and histories of histories. Although rigorous empirical validation is needed, bridging neuroscientific insights with clinical practice should open up avenues for research and intervention in complex neuropsychiatric features in people with FND.