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Background <p>Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling complication in breast cancer survivors that lacks effective treatments. This trial investigates whether meridian yoga, a therapy combining classical postures with meridian-based stretches, addresses the physiological effects of CIPN.</p> Methods: <p>This study is a single-centre, assessor-blinded, randomised controlled trial registered at ClinicalTrials.gov (NCT05959811). We randomised 80 stage I–III breast cancer survivors 1:1 to an eight-week meridian yoga programme plus standard care or standard care alone. Seventy-one participants (37 meridian yoga, 34 control) completed the study. The primary endpoint is the change in neuropathic pain symptoms assessed by the Taiwan version of the Neuropathic Pain Symptom Inventory (NPSI-T). Secondary outcomes include peripheral perfusion index (PPI), meridian energy, and salivary biomarkers (cortisol and interleukin-6 (IL-6)).</p> Results: <p>Compared with controls, the meridian yoga group achieves greater reductions in the NPSI-T total score (70.7 ± 24.2%; <i>P</i> = 4.2 × 10<sup>−12</sup>) across all domains. Participants in meridian yoga group show PPI normalisation in those with abnormal baseline circulation (<i>P</i> = 1.2 × 10<sup>−3</sup> for high, <i>P</i> = 4.6 × 10<sup>−2</sup> for low) and significant gains in overall bioenergetic indices (<i>P</i> ≤ 5.0 × 10<sup>−2</sup>/15). Levels of salivary cortisol and IL-6 remain unchanged. No serious adverse events occurred.</p> Conclusions: <p>Meridian yoga is a safe, feasible, and globally scalable intervention for CIPN survivorship care, with potential physiological markers for monitoring therapeutic responses.</p>

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Global applicability of meridian yoga for the improvement of neuropathic pain in breast cancer survivors: a single-blind randomised controlled trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月3日

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  • Chia‑Lin Tsai,
  • Ping Chuang,
  • Chih-Ying Liao,
  • Ying-Yu Chen,
  • Ting-Yi Liao,
  • Huang-Wei Lo,
  • Yu‑Huei Liu,
  • Ching‑Liang Hsieh

摘要

Background

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling complication in breast cancer survivors that lacks effective treatments. This trial investigates whether meridian yoga, a therapy combining classical postures with meridian-based stretches, addresses the physiological effects of CIPN.

Methods:

This study is a single-centre, assessor-blinded, randomised controlled trial registered at ClinicalTrials.gov (NCT05959811). We randomised 80 stage I–III breast cancer survivors 1:1 to an eight-week meridian yoga programme plus standard care or standard care alone. Seventy-one participants (37 meridian yoga, 34 control) completed the study. The primary endpoint is the change in neuropathic pain symptoms assessed by the Taiwan version of the Neuropathic Pain Symptom Inventory (NPSI-T). Secondary outcomes include peripheral perfusion index (PPI), meridian energy, and salivary biomarkers (cortisol and interleukin-6 (IL-6)).

Results:

Compared with controls, the meridian yoga group achieves greater reductions in the NPSI-T total score (70.7 ± 24.2%; P = 4.2 × 10−12) across all domains. Participants in meridian yoga group show PPI normalisation in those with abnormal baseline circulation (P = 1.2 × 10−3 for high, P = 4.6 × 10−2 for low) and significant gains in overall bioenergetic indices (P ≤ 5.0 × 10−2/15). Levels of salivary cortisol and IL-6 remain unchanged. No serious adverse events occurred.

Conclusions:

Meridian yoga is a safe, feasible, and globally scalable intervention for CIPN survivorship care, with potential physiological markers for monitoring therapeutic responses.