Scholarlink

<p>Pancreatic cancer remains one of the most lethal malignancies because most patients are diagnosed with advanced disease, when curative treatment is rarely possible. Population-wide screening is not currently recommended because pancreatic cancer remains relatively uncommon. Early detection efforts therefore focus on surveillance of individuals at substantially elevated risk, including those with hereditary cancer syndromes, pathogenic germline variants, or a strong family history of pancreatic cancer. Surveillance is primarily performed using magnetic resonance imaging and endoscopic ultrasound to detect early-stage cancer or high-risk precursor lesions. In this Review, we summarise current evidence for pancreatic cancer surveillance in high-risk populations. We discuss approaches to risk identification, surveillance eligibility, imaging strategies, and reported clinical outcomes. We also examine important challenges, including interval cancers, risk stratification, psychological impact, cost-effectiveness, and implementation in clinical practice. Finally, we review emerging approaches, including biomarkers and risk prediction models, that may further improve early detection.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Progress, challenges, and future directions of pancreatic cancer surveillance in high-risk populations

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年8月3日

查看全文
  • Ashleigh R. Poh,
  • Adrienne Sexton,
  • Halina Pietrzak,
  • Rebekah De Losa,
  • Raffiela Garcia,
  • Natalie Heriot,
  • Ingrid Winship,
  • Andrew J. Metz

摘要

Pancreatic cancer remains one of the most lethal malignancies because most patients are diagnosed with advanced disease, when curative treatment is rarely possible. Population-wide screening is not currently recommended because pancreatic cancer remains relatively uncommon. Early detection efforts therefore focus on surveillance of individuals at substantially elevated risk, including those with hereditary cancer syndromes, pathogenic germline variants, or a strong family history of pancreatic cancer. Surveillance is primarily performed using magnetic resonance imaging and endoscopic ultrasound to detect early-stage cancer or high-risk precursor lesions. In this Review, we summarise current evidence for pancreatic cancer surveillance in high-risk populations. We discuss approaches to risk identification, surveillance eligibility, imaging strategies, and reported clinical outcomes. We also examine important challenges, including interval cancers, risk stratification, psychological impact, cost-effectiveness, and implementation in clinical practice. Finally, we review emerging approaches, including biomarkers and risk prediction models, that may further improve early detection.