Scholarlink

Background <p>Treatment adaptation is particularly critical in particle therapy, where even small range deviations can compromise target coverage or lead to unintended dose delivered to surrounding healthy tissues. In-beam positron emission tomography (PET) has emerged as a promising approach for range verification during irradiation with protons or stable carbon ion beams. However, its clinical use is limited by low signal-to-noise ratio and by the spatial mismatch between activity and dose distributions, reducing verification accuracy and limiting timely intervention.</p> Methods <p>We used radioactive ion beams for real-time range adaptation in 10 weeks old C3H/ HeNRj female mice bearing LM8-osteosarcoma tumors. Three <sup>11</sup>C beam range settings were planned: short (S), right (R), and long (L). The range of a collimated monoenergetic probing beam was monitored in real-time with the SIRMIO in-beam PET scanner by tracking the activity peak along the beam path, while range adaptation was achieved with a remotely controlled range shifter. Each plan (S, R and L) was also delivered, and tumor growth, toxicity assays, and histological analyses were performed to evaluate each treatment outcomes.</p> Results <p>Dynamic repositioning of the <sup>11</sup>C beam produced spatially resolved PET signals that correlated with distinct biological outcomes. Toxicity was observed only in the L group, while adequate tumor coverage was achieved in both R and L groups. In contrast, the S group showed continued tumor growth.</p> Conclusions <p>We provide the first demonstration that in-beam imaging of radioactive ion beams can enable real-time range-guided radiotherapy in a living organism. These findings establish radioactive ion beams as a promising platform for precision range-guided particle therapy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Radioactive ion beam range adaptation in mouse tumors using in-beam PET

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月14日

查看全文
  • Martina Moglioni,
  • Tamara Vitacchio,
  • Francesco Evangelista,
  • Munetaka Nitta,
  • Daria Boscolo,
  • Giulio Lovatti,
  • Olga Sokol,
  • Emma Haettner,
  • Sivaji Purushothaman,
  • Walter Tinganelli,
  • Christian Graeff,
  • Uli Weber,
  • Christoph Schuy,
  • Andreas Bückner,
  • Gabriele Corbetta,
  • Leonard Doyle,
  • Lennart Volz,
  • Maria Chiara Martire,
  • Tim Wagner,
  • Alexander Helm,
  • Collin Werkheiser,
  • Daria Kostyleva,
  • Rinku Prajapat,
  • Suraj Kumar Singh,
  • Elena Rocco,
  • Jonathan Bortfeldt,
  • Peter G. Thirolf,
  • Christoph Scheidenberger,
  • Katia Parodi,
  • Marco Durante

摘要

Background

Treatment adaptation is particularly critical in particle therapy, where even small range deviations can compromise target coverage or lead to unintended dose delivered to surrounding healthy tissues. In-beam positron emission tomography (PET) has emerged as a promising approach for range verification during irradiation with protons or stable carbon ion beams. However, its clinical use is limited by low signal-to-noise ratio and by the spatial mismatch between activity and dose distributions, reducing verification accuracy and limiting timely intervention.

Methods

We used radioactive ion beams for real-time range adaptation in 10 weeks old C3H/ HeNRj female mice bearing LM8-osteosarcoma tumors. Three 11C beam range settings were planned: short (S), right (R), and long (L). The range of a collimated monoenergetic probing beam was monitored in real-time with the SIRMIO in-beam PET scanner by tracking the activity peak along the beam path, while range adaptation was achieved with a remotely controlled range shifter. Each plan (S, R and L) was also delivered, and tumor growth, toxicity assays, and histological analyses were performed to evaluate each treatment outcomes.

Results

Dynamic repositioning of the 11C beam produced spatially resolved PET signals that correlated with distinct biological outcomes. Toxicity was observed only in the L group, while adequate tumor coverage was achieved in both R and L groups. In contrast, the S group showed continued tumor growth.

Conclusions

We provide the first demonstration that in-beam imaging of radioactive ion beams can enable real-time range-guided radiotherapy in a living organism. These findings establish radioactive ion beams as a promising platform for precision range-guided particle therapy.