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<p>Sub-Saharan Africa bears a high burden of both malaria in pregnancy and hypertensive disorders of pregnancy including preeclampsia, a leading cause of maternal and perinatal deaths. Increasing evidence suggests that infection with <i>Plasmodium falciparum</i>, which causes placental malaria, is associated with increased preeclampsia risk. Here we discuss how epidemiologic and biological evidence link malaria to preeclampsia by examining shared pathways, including placental inflammation and vascular disruptions, which culminate in the unifying phenomenon of placental dysfunction in both syndromes. With these shared mechanisms in mind, we discuss how malaria prevention strategies could reduce the risk of preeclampsia and related long-term cardiovascular disease in endemic settings. We also outline key research and implementation priorities to support integrated prevention approaches in affected settings.</p>

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Evidence and opportunities for preeclampsia and cardiovascular disease prevention in malaria endemic settings

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月2日

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  • Ifeoma M. Obionu,
  • Julie M. Moore,
  • Safiya Zahradeen,
  • Hadiza Galadanci,
  • Mark D. Huffman,
  • Zainab Mahmoud

摘要

Sub-Saharan Africa bears a high burden of both malaria in pregnancy and hypertensive disorders of pregnancy including preeclampsia, a leading cause of maternal and perinatal deaths. Increasing evidence suggests that infection with Plasmodium falciparum, which causes placental malaria, is associated with increased preeclampsia risk. Here we discuss how epidemiologic and biological evidence link malaria to preeclampsia by examining shared pathways, including placental inflammation and vascular disruptions, which culminate in the unifying phenomenon of placental dysfunction in both syndromes. With these shared mechanisms in mind, we discuss how malaria prevention strategies could reduce the risk of preeclampsia and related long-term cardiovascular disease in endemic settings. We also outline key research and implementation priorities to support integrated prevention approaches in affected settings.