Scholarlink

Background <p>Chronic lung disease in very low birthweight infants involves complex, inflammation-driven lung injury. This study aimed to assess whether C-reactive protein levels during the first 28 days of life predict lung function at five to six years of age.</p> Methods <p>In this multicentre observational study, infants with a birthweight below 1500 grams and born between 2009 and 2015 were included. A C-reactive protein concentration above 10 mg/L was considered elevated. Recurrent elevations were defined as at least two values above this threshold separated by 14 days or more, with an interim decrease below 5 mg/L. Lung function was assessed by spirometry and running endurance at school age. Analyses included univariate tests and linear regression models adjusted for relevant risk factors.</p> Results <p>Here we show that among 268 infants with a median gestational age of 27.6 (25.7–29.4) weeks, those with recurrent C-reactive protein elevations had higher rates of bronchopulmonary dysplasia (56.3% versus 29.4%, p &lt; 0.027) and a greater proportion of children with forced expiratory volume in one second below the fifth percentile (71.9% versus 61.8%, p &lt; 0.001), and reduced running endurance. Recurrent elevations showed a high positive predictive value (71.9%) but low sensitivity (20.2%) for detecting severely reduced lung function.</p> Conclusions <p>The absence of recurrent C-reactive protein elevations in the neonatal period is associated with better long-term pulmonary outcomes and physical performance. These findings suggest that early inflammatory activity contributes to adverse lung development and support incorporating inflammatory biomarkers into multivariable models for early risk stratification.</p> <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Predictive value of increased C-reactive protein levels in preterm infants on respiratory function at five to six years of age

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月1日

查看全文
  • Mats Ingmar Fortmann,
  • Rebecca Dappen,
  • Claudia Roll,
  • Margarita Kozhuharova,
  • Axel von der Wense,
  • Christoph Härtel,
  • Julia Sandkötter,
  • Egbert Herting,
  • Wolfgang Göpel,
  • Alexander Humberg

摘要

Background

Chronic lung disease in very low birthweight infants involves complex, inflammation-driven lung injury. This study aimed to assess whether C-reactive protein levels during the first 28 days of life predict lung function at five to six years of age.

Methods

In this multicentre observational study, infants with a birthweight below 1500 grams and born between 2009 and 2015 were included. A C-reactive protein concentration above 10 mg/L was considered elevated. Recurrent elevations were defined as at least two values above this threshold separated by 14 days or more, with an interim decrease below 5 mg/L. Lung function was assessed by spirometry and running endurance at school age. Analyses included univariate tests and linear regression models adjusted for relevant risk factors.

Results

Here we show that among 268 infants with a median gestational age of 27.6 (25.7–29.4) weeks, those with recurrent C-reactive protein elevations had higher rates of bronchopulmonary dysplasia (56.3% versus 29.4%, p < 0.027) and a greater proportion of children with forced expiratory volume in one second below the fifth percentile (71.9% versus 61.8%, p < 0.001), and reduced running endurance. Recurrent elevations showed a high positive predictive value (71.9%) but low sensitivity (20.2%) for detecting severely reduced lung function.

Conclusions

The absence of recurrent C-reactive protein elevations in the neonatal period is associated with better long-term pulmonary outcomes and physical performance. These findings suggest that early inflammatory activity contributes to adverse lung development and support incorporating inflammatory biomarkers into multivariable models for early risk stratification.