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Background <p>SARS-CoV-2 infection usually has a mild course in childhood, yet few children develop a Multisystem Inflammatory Syndrome (MIS-C). Several metabolic pathways have been found to be dysregulated in adults with COVID-19, yet data are lacking in children. Here we investigate serum metabolomic features of children with COVID-19 in relation to age, sex and both clinical and biochemical severity.</p> Methods <p>We carried out a prospective observational comparative cohort study enrolling 92 children (48 M, mean age 3.69 ± 5.1 years) with acute SARS-CoV-2 infection and 7 with MIS-C along with 41 age- and sex-matched controls. Sera collected at admission, acute phase, discharge and remission were analyzed by Gas Chromatography Mass Spectroscopy.</p> Results <p>Here we identify a distinct signature featuring inflammation, reactive oxygen species and glicerolipids pathways in children with acute SARS-CoV-2 infection compared to controls (permutation test p = 0.0015). Metabolomic profile changes are associated with age, disease status and disease severity, while a normalization of these changes is observed at disease resolution. MIS-C children showed a unique signature compared to age-/sex-matched COVID-19 patients or controls.</p> Conclusions <p>Pediatric COVID-19 has a characteristic metabolomic signature featuring glucose and aminoacid metabolism, that varies with age and disease phenotype. Our study supports the value of metabolomics to unveil pathways related to host-viral interaction that may also help identify early predictors of disease evolution.</p>

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A longitudinal comparative analysis of serum metabolomic signatures in children with SARS-CoV-2 infection and MIS-C

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月27日

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  • A. Lo Vecchio,
  • V. Discepolo,
  • L. Pierri,
  • A. Catzola,
  • M. Lombardi,
  • A. Colucci,
  • M. Poeta,
  • E. Bruzzese,
  • J. Troisi,
  • A. Guarino

摘要

Background

SARS-CoV-2 infection usually has a mild course in childhood, yet few children develop a Multisystem Inflammatory Syndrome (MIS-C). Several metabolic pathways have been found to be dysregulated in adults with COVID-19, yet data are lacking in children. Here we investigate serum metabolomic features of children with COVID-19 in relation to age, sex and both clinical and biochemical severity.

Methods

We carried out a prospective observational comparative cohort study enrolling 92 children (48 M, mean age 3.69 ± 5.1 years) with acute SARS-CoV-2 infection and 7 with MIS-C along with 41 age- and sex-matched controls. Sera collected at admission, acute phase, discharge and remission were analyzed by Gas Chromatography Mass Spectroscopy.

Results

Here we identify a distinct signature featuring inflammation, reactive oxygen species and glicerolipids pathways in children with acute SARS-CoV-2 infection compared to controls (permutation test p = 0.0015). Metabolomic profile changes are associated with age, disease status and disease severity, while a normalization of these changes is observed at disease resolution. MIS-C children showed a unique signature compared to age-/sex-matched COVID-19 patients or controls.

Conclusions

Pediatric COVID-19 has a characteristic metabolomic signature featuring glucose and aminoacid metabolism, that varies with age and disease phenotype. Our study supports the value of metabolomics to unveil pathways related to host-viral interaction that may also help identify early predictors of disease evolution.