Scholarlink

Background: <p>Biological age derived from DNA methylation (mAge) reflects aging-related physiological changes and the risk of age-related diseases. However, the association between oral microbiome and mAge remains unclear.</p> Methods: <p>We examined associations between mAge, physical and cognitive function, and the oral microbiome in 311 community-dwelling, predominantly Chinese adults aged 85 years or older. Oral microbial composition was assessed using 16S rRNA sequencing, and mAge was estimated using four established epigenetic clocks: HorvathAge, HannumAge, PhenoAge, and GrimAge.</p> Results: <p>In this cohort (median chronological age = 88.6 years; median DNA methylation–based biological age = 81.4 years), individuals with lower mAge deviation, corresponding to a younger biological age, exhibit lower oral microbial alpha diversity based on Simpson’s index. While no taxa differences reach significance after correction for multiple testing, several short-chain fatty acid–producing genera, such as <i>Prevotella_7</i> and <i>Veillonella</i>, show nominal associations with both mAge deviation and methylation at aging-related CpG sites, particularly in neurologically relevant genes. Higher abundance of <i>Prevotella_7</i> species is associated with better cognitive performance (Mini-Mental State Examination), whereas <i>Alloprevotella</i> is linked to poorer cognition.</p> Conclusion: <p>Our findings highlight that, as far as we aware, previously unrecognized oral microbiome composition links to lower mAge deviation and better cognitive function among the oldest-old, suggesting a potential role of the oral microbiome in promoting healthy aging and informing future mechanistic investigations.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Oral short-chain fatty acid-producing bacteria may be associated with biological age and cognition among the oldest old

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月20日

查看全文
  • Tim Wehnes,
  • Weilan Wang,
  • Jian Hua Tay,
  • Lihuan Guan,
  • Lei Feng,
  • Chun Man Roger Ho,
  • Tze Pin Ng,
  • Brian K. Kennedy,
  • Ashok Venkitaraman,
  • Woon-Puay Koh,
  • Yap Seng Chong,
  • Andrea B. Maier

摘要

Background:

Biological age derived from DNA methylation (mAge) reflects aging-related physiological changes and the risk of age-related diseases. However, the association between oral microbiome and mAge remains unclear.

Methods:

We examined associations between mAge, physical and cognitive function, and the oral microbiome in 311 community-dwelling, predominantly Chinese adults aged 85 years or older. Oral microbial composition was assessed using 16S rRNA sequencing, and mAge was estimated using four established epigenetic clocks: HorvathAge, HannumAge, PhenoAge, and GrimAge.

Results:

In this cohort (median chronological age = 88.6 years; median DNA methylation–based biological age = 81.4 years), individuals with lower mAge deviation, corresponding to a younger biological age, exhibit lower oral microbial alpha diversity based on Simpson’s index. While no taxa differences reach significance after correction for multiple testing, several short-chain fatty acid–producing genera, such as Prevotella_7 and Veillonella, show nominal associations with both mAge deviation and methylation at aging-related CpG sites, particularly in neurologically relevant genes. Higher abundance of Prevotella_7 species is associated with better cognitive performance (Mini-Mental State Examination), whereas Alloprevotella is linked to poorer cognition.

Conclusion:

Our findings highlight that, as far as we aware, previously unrecognized oral microbiome composition links to lower mAge deviation and better cognitive function among the oldest-old, suggesting a potential role of the oral microbiome in promoting healthy aging and informing future mechanistic investigations.