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Background <p>Intrapancreatic fat deposition (IPFD) has been linked to impaired β cell function and development of type 2 diabetes (T2D). It remains unclear whether IPFD is associated with incident T2D independent of visceral adiposity. Sex differences in the associations of IPFD with T2D are also unclear. We aimed to investigate the sex-specific associations of IPFD with risk of incident T2D, and whether the associations are independent of hepatic fat and visceral fat.</p> Methods <p>This is a cohort study using data from the UK Biobank cohort. 22,703 participants with available magnetic resonance imaging (MRI)- derived adiposity measures and without diabetes at the imaging visit were included. The main exposure was MRI-measured IPFD. The main outcome was incident T2D.</p> Results <p>Here we show that IPFD is associated with risk of T2D in both men (HR 1.35, 95% CI 1.17–1.55) and women (HR 1.53, 95% CI 1.32–1.78). After adjusting for BMI or hepatic fat, IPFD remains significantly associated with incident T2D in both sexes. The association between IPFD and incident T2D remains significant in men adjusted for visceral fat (HR 1.22, CI 1.05–1.43). IPFD is no longer significantly associated with T2D adjusted for visceral fat in women (HR 1.19, CI 0.99–1.44).</p> Conclusions <p>In this large-scale cohort study, IPFD is associated with incident T2D independent of BMI, hepatic fat and visceral fat in men and independent of BMI and hepatic fat in women. The results suggest that IPFD is of additional predictive value for future T2D.</p>

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Sex-specific associations of intrapancreatic fat deposition with incident type 2 diabetes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月28日

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  • Xuechen Wang,
  • Yucheng Yang,
  • Shumeng Han,
  • Zijun Liu,
  • Fan Ping,
  • Wei Li,
  • Lingling Xu,
  • Huabing Zhang,
  • Yuxiu Li

摘要

Background

Intrapancreatic fat deposition (IPFD) has been linked to impaired β cell function and development of type 2 diabetes (T2D). It remains unclear whether IPFD is associated with incident T2D independent of visceral adiposity. Sex differences in the associations of IPFD with T2D are also unclear. We aimed to investigate the sex-specific associations of IPFD with risk of incident T2D, and whether the associations are independent of hepatic fat and visceral fat.

Methods

This is a cohort study using data from the UK Biobank cohort. 22,703 participants with available magnetic resonance imaging (MRI)- derived adiposity measures and without diabetes at the imaging visit were included. The main exposure was MRI-measured IPFD. The main outcome was incident T2D.

Results

Here we show that IPFD is associated with risk of T2D in both men (HR 1.35, 95% CI 1.17–1.55) and women (HR 1.53, 95% CI 1.32–1.78). After adjusting for BMI or hepatic fat, IPFD remains significantly associated with incident T2D in both sexes. The association between IPFD and incident T2D remains significant in men adjusted for visceral fat (HR 1.22, CI 1.05–1.43). IPFD is no longer significantly associated with T2D adjusted for visceral fat in women (HR 1.19, CI 0.99–1.44).

Conclusions

In this large-scale cohort study, IPFD is associated with incident T2D independent of BMI, hepatic fat and visceral fat in men and independent of BMI and hepatic fat in women. The results suggest that IPFD is of additional predictive value for future T2D.