Proteomic features of soft tissue tumours in adolescents and young adults

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2024年5月18日

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Yuen Bun Tam,
Kaan Low,
Hari PS,
Madhumeeta Chadha,
Jessica Burns,
Christopher P. Wilding,
Amani Arthur,
Tom W. Chen,
Khin Thway,
Anguraj Sadanandam,
Robin L. Jones,
Paul H. Huang

摘要

Background

Adolescents and young adult (AYA) patients with soft tissue tumours including sarcomas are an underserved group with disparities in treatment outcomes.

Methods

To define the molecular features between AYA and older adult (OA) patients, we analysed the proteomic profiles of a large cohort of soft tissue tumours across 10 histological subtypes (AYA n = 66, OA n = 243), and also analysed publicly available functional genomic data from soft tissue tumour cell lines (AYA n = 5, OA n = 8).

Results

Biological hallmarks analysis demonstrates that OA tumours are significantly enriched in MYC targets compared to AYA tumours. By comparing the patient-level proteomic data with functional genomic profiles from sarcoma cell lines, we show that the mRNA splicing pathway is an intrinsic vulnerability in cell lines from OA patients and that components of the spliceosome complex are independent prognostic factors for metastasis free survival in AYA patients.

Conclusions

Our study highlights the importance of performing age-specific molecular profiling studies to identify risk stratification tools and targeted agents tailored for the clinical management of AYA patients.