A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

• 期刊论文

• 发表日期：

  2025年2月7日

• Xihao Li,
• Han Chen,
• Margaret Sunitha Selvaraj,
• Eric Van Buren,
• Hufeng Zhou,
• Yuxuan Wang,
• Ryan Sun,
• Zachary R. McCaw,
• Zhi Yu,
• Min-Zhi Jiang,
• Daniel DiCorpo,
• Sheila M. Gaynor,
• Rounak Dey,
• Donna K. Arnett,
• Emelia J. Benjamin,
• Joshua C. Bis,
• John Blangero,
• Eric Boerwinkle,
• Donald W. Bowden,
• Jennifer A. Brody,
• Brian E. Cade,
• April P. Carson,
• Jenna C. Carlson,
• Nathalie Chami,
• Yii-Der Ida Chen,
• Joanne E. Curran,
• Paul S. de Vries,
• Myriam Fornage,
• Nora Franceschini,
• Barry I. Freedman,
• Charles Gu,
• Nancy L. Heard-Costa,
• Jiang He,
• Lifang Hou,
• Yi-Jen Hung,
• Marguerite R. Irvin,
• Robert C. Kaplan,
• Sharon L. R. Kardia,
• Tanika N. Kelly,
• Iain Konigsberg,
• Charles Kooperberg,
• Brian G. Kral,
• Changwei Li,
• Yun Li,
• Honghuang Lin,
• Ching-Ti Liu,
• Ruth J. F. Loos,
• Michael C. Mahaney,
• Lisa W. Martin,
• Rasika A. Mathias,
• Braxton D. Mitchell,
• May E. Montasser,
• Alanna C. Morrison,
• Take Naseri,
• Kari E. North,
• Nicholette D. Palmer,
• Patricia A. Peyser,
• Bruce M. Psaty,
• Susan Redline,
• Alexander P. Reiner,
• Stephen S. Rich,
• Colleen M. Sitlani,
• Jennifer A. Smith,
• Kent D. Taylor,
• Hemant K. Tiwari,
• Ramachandran S. Vasan,
• Satupa’itea Viali,
• Zhe Wang,
• Jennifer Wessel,
• Lisa R. Yanek,
• Bing Yu,
• Namiko Abe,
• Gonçalo Abecasis,
• Francois Aguet,
• Christine Albert,
• Laura Almasy,
• Alvaro Alonso,
• Seth Ament,
• Peter Anderson,
• Pramod Anugu,
• Deborah Applebaum-Bowden,
• Kristin Ardlie,
• Dan Arking,
• Allison Ashley-Koch,
• Stella Aslibekyan,
• Tim Assimes,
• Dimitrios Avramopoulos,
• Najib Ayas,
• Adithya Balasubramanian,
• John Barnard,
• Kathleen Barnes,
• R. Graham Barr,
• Emily Barron-Casella,
• Lucas Barwick,
• Terri Beaty,
• Gerald Beck,
• Diane Becker,
• Lewis Becker,
• Rebecca Beer,
• Amber Beitelshees,
• Takis Benos,
• Marcos Bezerra,
• Larry Bielak,
• Thomas Blackwell,
• Nathan Blue,
• Russell Bowler,
• Ulrich Broeckel,
• Jai Broome,
• Deborah Brown,
• Karen Bunting,
• Esteban Burchard,
• Carlos Bustamante,
• Erin Buth,
• Jonathan Cardwell,
• Vincent Carey,
• Julie Carrier,
• Cara Carty,
• Richard Casaburi,
• Juan P. Casas Romero,
• James Casella,
• Peter Castaldi,
• Mark Chaffin,
• Christy Chang,
• Yi-Cheng Chang,
• Daniel Chasman,
• Sameer Chavan,
• Bo-Juen Chen,
• Wei-Min Chen,
• Michael Cho,
• Seung Hoan Choi,
• Lee-Ming Chuang,
• Mina Chung,
• Ren-Hua Chung,
• Clary Clish,
• Suzy Comhair,
• Matthew Conomos,
• Elaine Cornell,
• Adolfo Correa,
• Carolyn Crandall,
• James Crapo,
• L. Adrienne Cupples,
• Jeffrey Curtis,
• Brian Custer,
• Coleen Damcott,
• Dawood Darbar,
• Sean David,
• Colleen Davis,
• Michelle Daya,
• Michael DeBaun,
• Dawn DeMeo,
• Ranjan Deka,
• Scott Devine,
• Huyen Dinh,
• Harsha Doddapaneni,
• Qing Duan,
• Shannon Dugan-Perez,
• Ravi Duggirala,
• Jon Peter Durda,
• Susan K. Dutcher,
• Charles Eaton,
• Lynette Ekunwe,
• Adel El Boueiz,
• Patrick T. Ellinor,
• Leslie Emery,
• Serpil Erzurum,
• Charles Farber,
• Jesse Farek,
• Tasha Fingerlin,
• Matthew Flickinger,
• Chris Frazar,
• Mao Fu,
• Stephanie M. Fullerton,
• Lucinda Fulton,
• Stacey Gabriel,
• Weiniu Gan,
• Shanshan Gao,
• Yan Gao,
• Margery Gass,
• Heather Geiger,
• Bruce Gelb,
• Mark Geraci,
• Soren Germer,
• Robert Gerszten,
• Auyon Ghosh,
• Richard Gibbs,
• Chris Gignoux,
• Mark Gladwin,
• David Glahn,
• Stephanie Gogarten,
• Da-Wei Gong,
• Harald Goring,
• Sharon Graw,
• Kathryn J. Gray,
• Daniel Grine,
• Colin Gross,
• Yue Guan,
• Xiuqing Guo,
• Namrata Gupta,
• Jeff Haessler,
• Michael Hall,
• Yi Han,
• Patrick Hanly,
• Daniel Harris,
• Nicola L. Hawley,
• Ben Heavner,
• Susan Heckbert,
• Ryan Hernandez,
• David Herrington,
• Craig Hersh,
• Bertha Hidalgo,
• James Hixson,
• Brian Hobbs,
• John Hokanson,
• Elliott Hong,
• Karin Hoth,
• Chao Agnes Hsiung,
• Jianhong Hu,
• Haley Huston,
• Chii Min Hwu,
• Rebecca Jackson,
• Deepti Jain,
• Cashell Jaquish,
• Jill Johnsen,
• Andrew Johnson,
• Craig Johnson,
• Rich Johnston,
• Kimberly Jones,
• Hyun Min Kang,
• Shannon Kelly,
• Eimear Kenny,
• Michael Kessler,
• Alyna Khan,
• Ziad Khan,
• Wonji Kim,
• John Kimoff,
• Greg Kinney,
• Barbara Konkle,
• Holly Kramer,
• Christoph Lange,
• Ethan Lange,
• Leslie Lange,
• Cathy Laurie,
• Cecelia Laurie,
• Meryl LeBoff,
• Jonathon LeFaive,
• Jiwon Lee,
• Sandra Lee,
• Wen-Jane Lee,
• David Levine,
• Daniel Levy,
• Joshua Lewis,
• Xiaohui Li,
• Henry Lin,
• Simin Liu,
• Yongmei Liu,
• Yu Liu,
• Steven A. Lubitz,
• Kathryn L. Lunetta,
• James Luo,
• Ulysses Magalang,
• Barry Make,
• Ani Manichaikul,
• JoAnn Manson,
• Melissa Marton,
• Susan Mathai,
• Susanne May,
• Patrick McArdle,
• Merry-Lynn McDonald,
• Sean McFarland,
• Stephen McGarvey,
• Daniel McGoldrick,
• Caitlin McHugh,
• Becky McNeil,
• Hao Mei,
• Vipin Menon,
• Luisa Mestroni,
• Ginger Metcalf,
• Deborah A. Meyers,
• Emmanuel Mignot,
• Julie Mikulla,
• Nancy Min,
• Mollie Minear,
• Ryan L. Minster,
• Matt Moll,
• Zeineen Momin,
• Courtney Montgomery,
• Donna Muzny,
• Josyf C. Mychaleckyj,
• Girish Nadkarni,
• Rakhi Naik,
• Sergei Nekhai,
• Sarah C. Nelson,
• Bonnie Neltner,
• Caitlin Nessner,
• Deborah Nickerson,
• Osuji Nkechinyere,
• Jeff O’Connell,
• Tim O’Connor,
• Heather Ochs-Balcom,
• Geoffrey Okwuonu,
• Allan Pack,
• David T. Paik,
• James Pankow,
• George Papanicolaou,
• Cora Parker,
• Juan Manuel Peralta,
• Marco Perez,
• James Perry,
• Ulrike Peters,
• Lawrence S. Phillips,
• Jacob Pleiness,
• Toni Pollin,
• Wendy Post,
• Julia Powers Becker,
• Meher Preethi Boorgula,
• Michael Preuss,
• Pankaj Qasba,
• Dandi Qiao,
• Zhaohui Qin,
• Nicholas Rafaels,
• Mahitha Rajendran,
• D. C. Rao,
• Laura Rasmussen-Torvik,
• Aakrosh Ratan,
• Robert Reed,
• Catherine Reeves,
• Elizabeth Regan,
• Muagututi’a Sefuiva Reupena,
• Rebecca Robillard,
• Nicolas Robine,
• Dan Roden,
• Carolina Roselli,
• Ingo Ruczinski,
• Alexi Runnels,
• Pamela Russell,
• Sarah Ruuska,
• Kathleen Ryan,
• Ester Cerdeira Sabino,
• Danish Saleheen,
• Shabnam Salimi,
• Sejal Salvi,
• Steven Salzberg,
• Kevin Sandow,
• Vijay G. Sankaran,
• Jireh Santibanez,
• Karen Schwander,
• David Schwartz,
• Frank Sciurba,
• Christine Seidman,
• Jonathan Seidman,
• Vivien Sheehan,
• Stephanie L. Sherman,
• Amol Shetty,
• Aniket Shetty,
• Wayne Hui-Heng Sheu,
• M. Benjamin Shoemaker,
• Brian Silver,
• Edwin Silverman,
• Robert Skomro,
• Albert Vernon Smith,
• Josh Smith,
• Nicholas Smith,
• Tanja Smith,
• Sylvia Smoller,
• Beverly Snively,
• Michael Snyder,
• Tamar Sofer,
• Nona Sotoodehnia,
• Adrienne M. Stilp,
• Garrett Storm,
• Elizabeth Streeten,
• Jessica Lasky Su,
• Yun Ju Sung,
• Jody Sylvia,
• Adam Szpiro,
• Frédéric Sériès,
• Daniel Taliun,
• Hua Tang,
• Margaret Taub,
• Matthew Taylor,
• Simeon Taylor,
• Marilyn Telen,
• Timothy A. Thornton,
• Machiko Threlkeld,
• Lesley Tinker,
• David Tirschwell,
• Sarah Tishkoff,
• Catherine Tong,
• Russell Tracy,
• Michael Tsai,
• Dhananjay Vaidya,
• David Van Den Berg,
• Peter VandeHaar,
• Scott Vrieze,
• Tarik Walker,
• Robert Wallace,
• Avram Walts,
• Fei Fei Wang,
• Heming Wang,
• Jiongming Wang,
• Karol Watson,
• Jennifer Watt,
• Daniel E. Weeks,
• Joshua Weinstock,
• Bruce Weir,
• Scott T. Weiss,
• Lu-Chen Weng,
• Cristen Willer,
• Kayleen Williams,
• L. Keoki Williams,
• Scott Williams,
• Carla Wilson,
• James Wilson,
• Lara Winterkorn,
• Quenna Wong,
• Baojun Wu,
• Joseph Wu,
• Huichun Xu,
• Ivana Yang,
• Ketian Yu,
• Seyedeh Maryam Zekavat,
• Yingze Zhang,
• Snow Xueyan Zhao,
• Wei Zhao,
• Xiaofeng Zhu,
• Elad Ziv,
• Michael Zody,
• Sebastian Zoellner,
• Mariza de Andrade,
• Lisa de las Fuentes,
• Josée Dupuis,
• James B. Meigs,
• Paul L. Auer,
• Laura M. Raffield,
• Alisa K. Manning,
• Kenneth M. Rice,
• Jerome I. Rotter,
• Gina M. Peloso,
• Pradeep Natarajan,
• Zilin Li,
• Zhonghua Liu,
• Xihong Lin