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<p>Torpor and hibernation are extreme physiological adaptations of homeotherms associated with pro-longevity effects. Yet the underlying mechanisms of how torpor affects aging, and whether hypothermic and hypometabolic states can be induced to slow aging and increase healthspan, remain unknown. Here we demonstrate that the activity of a spatially defined neuronal population in the preoptic area, which has previously been identified as a torpor-regulating brain region, is sufficient to induce a torpor-like state (TLS) in mice. Prolonged induction of TLS slows epigenetic aging across multiple tissues and improves healthspan. We isolate the effects of decreased metabolic rate, long-term caloric restriction, and decreased core body temperature (<i>T</i><sub>b</sub>) on blood epigenetic aging and find that the decelerating effect of TLSs on aging is mediated by decreased <i>T</i><sub>b</sub>. Taken together, our findings provide novel mechanistic insight into the decelerating effects of torpor and hibernation on aging and support the growing body of evidence that <i>T</i><sub>b</sub> is an important mediator of the aging processes.</p>

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A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月7日

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  • Lorna Jayne,
  • Aurora Lavin-Peter,
  • Julian Roessler,
  • Alexander Tyshkovskiy,
  • Mateusz Antoszewski,
  • Erika Ren,
  • Aleksandar Markovski,
  • Senmiao Sun,
  • Hanqi Yao,
  • Vijay G. Sankaran,
  • Vadim N. Gladyshev,
  • Robert T. Brooke,
  • Steve Horvath,
  • Eric C. Griffith,
  • Sinisa Hrvatin

摘要

Torpor and hibernation are extreme physiological adaptations of homeotherms associated with pro-longevity effects. Yet the underlying mechanisms of how torpor affects aging, and whether hypothermic and hypometabolic states can be induced to slow aging and increase healthspan, remain unknown. Here we demonstrate that the activity of a spatially defined neuronal population in the preoptic area, which has previously been identified as a torpor-regulating brain region, is sufficient to induce a torpor-like state (TLS) in mice. Prolonged induction of TLS slows epigenetic aging across multiple tissues and improves healthspan. We isolate the effects of decreased metabolic rate, long-term caloric restriction, and decreased core body temperature (Tb) on blood epigenetic aging and find that the decelerating effect of TLSs on aging is mediated by decreased Tb. Taken together, our findings provide novel mechanistic insight into the decelerating effects of torpor and hibernation on aging and support the growing body of evidence that Tb is an important mediator of the aging processes.