<p>Nitrogen (N) cycling has been reshaped during the Anthropocene epoch, yet the global change pattern of sedimentary N stable isotope (δ¹⁵N) remains unclear. Previous research has mainly focused on changes of sedimentary δ¹⁵N in remote areas or during the Holocene epoch, yet the differentiation of sedimentary δ¹⁵N between remote areas and disturbed regions and the onset of the differentiation time are neglected in the Anthropocene epoch. Here we synthesized published records of well-dated δ¹⁵N abundance in sedimentary sequences from 173 sites globally, including natural and disturbed areas, and proposed a conceptual diagram to descript the global change patterns of sedimentary δ¹⁵N in past 300 years. Sedimentary δ¹⁵N in disturbed sites enriched, with two breakpoints in 1910s and 1950s. The other one, δ¹⁵N trend in natural sites mostly depleted, with a breakpoint in 1920s. The timeline aligns with unprecedented anthropic perturbations to the global N cycle, such as the invention and application of the Haber-Bosch process. The divergence of δ¹⁵N change pattern between disturbed and natural areas can be attributed to either direct human activities or indirect consequences. Taken together, we propose that the 1910s − 1930s can be considered the precursor of the Anthropocene due to the application of artificial N fixation and its consequent biogeochemical effect. We emphasize that the Haber-Bosch process could be the important event before the impact of human activities on Earth history is reflected in global stratigraphy.</p>