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<p>Tissue engineering devices stabilize wounds, then degrade. However, published degradation rates often conflict. Incorporating monitoring functionality into devices allows real-time assessment of degradation and failure, but requires contrast agents, as polymer devices are invisible to most medical imaging modalities. Therefore, computed tomography (CT)-visible composite scaffolds were created from 5-20 wt% tantalum oxide (TaO<sub>x</sub>) nanoparticles in polymers with distinct degradation profiles: polycaprolactone, poly(lactide-co-glycolide) (PLGA) 85:15 and PLGA 50:50, representing slow, medium and fast degrading materials. Scaffolds, mimicking biomedical devices, were implanted into mice intramuscularly or intraperitoneally, and monitored via CT over 20 weeks. Scaffold degradation profile was dictated by polymer matrix, regardless of nanoparticle addition. Foreign body response was dependent on implant site and in mid-degrading composites degradation rates transitioned from linear degradation intramuscularly to exponential degradation intraperitoneally. Nanoparticle excretion via liver and spleen lagged polymer degradation. Overall, real time tracking of device behavior was demonstrated, advancing an era of personalized medicine.</p><p></p>

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In vivo study of the effect of composition and implantation site on scaffold degradation rate

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月24日

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  • Kendell M. Pawelec,
  • Jeremy M. L. Hix,
  • Arianna Troia,
  • Niharika Sinha,
  • Keith W. MacRenaris,
  • Matti Kiupel,
  • Thomas V. O’Halloran,
  • Erik M. Shapiro

摘要

Tissue engineering devices stabilize wounds, then degrade. However, published degradation rates often conflict. Incorporating monitoring functionality into devices allows real-time assessment of degradation and failure, but requires contrast agents, as polymer devices are invisible to most medical imaging modalities. Therefore, computed tomography (CT)-visible composite scaffolds were created from 5-20 wt% tantalum oxide (TaOx) nanoparticles in polymers with distinct degradation profiles: polycaprolactone, poly(lactide-co-glycolide) (PLGA) 85:15 and PLGA 50:50, representing slow, medium and fast degrading materials. Scaffolds, mimicking biomedical devices, were implanted into mice intramuscularly or intraperitoneally, and monitored via CT over 20 weeks. Scaffold degradation profile was dictated by polymer matrix, regardless of nanoparticle addition. Foreign body response was dependent on implant site and in mid-degrading composites degradation rates transitioned from linear degradation intramuscularly to exponential degradation intraperitoneally. Nanoparticle excretion via liver and spleen lagged polymer degradation. Overall, real time tracking of device behavior was demonstrated, advancing an era of personalized medicine.