Scholarlink

<p>Stimuli‑responsive (smart) biomaterials are emerging as versatile platforms for the precision delivery of biotherapeutics. Engineered to sense internal or external cues, these materials undergo reversible physicochemical changes that trigger on‑demand payload release, thus improving efficacy while limiting off‑target toxicity. Here we synthesize the design principles that underpin materials’ selection, architecture, and functionalization and provide a systematic classification of triggering stimuli spanning physical (temperature, light, ultrasound), chemical (pH, redox potential, ionic strength), and biological (enzymes, glucose, reactive oxygen species) cues, including multi‑responsive systems that integrate signals for synergistic control. We describe mechanistic pathways of stimuli transduction and release that enable spatiotemporal dosing. We then survey recent advances in the delivery of small molecules, proteins and peptides, nucleic‑acid therapeutics (DNA, RNA, CRISPR components), vaccines and cells using these platforms, and evaluate their translational potential in targeted therapy and regenerative medicine. Finally, we discuss outstanding challenges, safety, manufacturability, and reproducibility, and outline directions for next‑generation biomaterials capable of intelligent, site‑specific delivery.</p><p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Delivering biomedicines with stimuli‑responsive biomaterials

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月8日

查看全文
  • Hemant Singh,
  • Zenab Darban,
  • Aliakbar Ebrahimi,
  • Atif Khurshid Wani,
  • Showkeen Muzamil Bashir,
  • Huseyin Avci,
  • Syed Shahabuddin,
  • Rukshana Mangattu Veettil,
  • Fawzi Banat,
  • Shabir Hassan

摘要

Stimuli‑responsive (smart) biomaterials are emerging as versatile platforms for the precision delivery of biotherapeutics. Engineered to sense internal or external cues, these materials undergo reversible physicochemical changes that trigger on‑demand payload release, thus improving efficacy while limiting off‑target toxicity. Here we synthesize the design principles that underpin materials’ selection, architecture, and functionalization and provide a systematic classification of triggering stimuli spanning physical (temperature, light, ultrasound), chemical (pH, redox potential, ionic strength), and biological (enzymes, glucose, reactive oxygen species) cues, including multi‑responsive systems that integrate signals for synergistic control. We describe mechanistic pathways of stimuli transduction and release that enable spatiotemporal dosing. We then survey recent advances in the delivery of small molecules, proteins and peptides, nucleic‑acid therapeutics (DNA, RNA, CRISPR components), vaccines and cells using these platforms, and evaluate their translational potential in targeted therapy and regenerative medicine. Finally, we discuss outstanding challenges, safety, manufacturability, and reproducibility, and outline directions for next‑generation biomaterials capable of intelligent, site‑specific delivery.