<p>The fabrication and advancement of multifunctional nanomaterials have long been a focus of attention in applied research. This is primarily attributed to their ability to integrate multiple desirable properties into a single material system, which not only enhances operational efficiency but also reduces the reliance on complex multi-component systems. Using a facile physical approach, we synthesized multifunctional metallic alloy nanomushrooms on nanowire featuring high-targeting precision and intense photoluminescence. The alloy core of the nanomushrooms, with superior electrical conductivity, significantly improves photothermal conversion efficiency. Meanwhile, their unique mushroom-like morphology enables dense loading of targeting molecules. This design allows simultaneous tumor cell visualization via enhanced fluorescence and their elimination via photothermal ablation. Experimental validation confirms its potential as a theranostic agent, overcoming limitations of current photoluminescent nanomaterials in biomedicine.</p>