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<p>Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) levels in blood and tissues are widely proposed to decline with age, yet evidence in human blood is inconsistent. Using a rigorously validated ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry system that accounts for real-world analytical variability, we quantify NAD<sup>+</sup> across seven independent human cohorts. We find that whole-blood NAD<sup>+</sup> levels remain remarkably stable with age and across lifestyle interventions, but change in response to nicotinamide riboside supplementation, as expected. Our results challenge the utility of blood NAD<sup>+</sup> levels as a biomarker of ageing or lifestyle factors.</p>

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Human whole-blood NAD+ levels do not vary with age or lifestyle interventions

  • 期刊论文

  • 发表日期：

    2026年5月14日

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  • Maria M. Trętowicz,
  • Angelique M. L. Scantlebery,
  • Bauke V. Schomakers,
  • Kaan D. Eroğlu,
  • Michel van Weeghel,
  • Vera Spek,
  • Kasper T. Vinten,
  • Luc Legon,
  • Evrim Coskun,
  • Fernando Millan-Domingo,
  • Gloria Olaso-Gonzalez,
  • Maria Carmen Gomez-Cabrera,
  • Silvia Montoro-García,
  • Clara Noguera-Navarro,
  • André B. P. van Kuilenburg,
  • Sofia Moco,
  • Juliette C. van Hattum,
  • Harald T. Jørstad,
  • Mohammed Benali,
  • Jantine van der Helder,
  • Esmee J. M. Biersteker,
  • Maheswary Muniandy,
  • Kirsi H. Pietiläinen,
  • Eija Pirinen,
  • P. Eline Slagboom,
  • Marian Beekman,
  • Joris Deelen,
  • Rubén Zapata-Pérez,
  • Peter J. M. Weijs,
  • Michael Tieland,
  • Georges E. Janssens,
  • Riekelt H. Houtkooper

摘要

Nicotinamide adenine dinucleotide (NAD+) levels in blood and tissues are widely proposed to decline with age, yet evidence in human blood is inconsistent. Using a rigorously validated ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry system that accounts for real-world analytical variability, we quantify NAD+ across seven independent human cohorts. We find that whole-blood NAD+ levels remain remarkably stable with age and across lifestyle interventions, but change in response to nicotinamide riboside supplementation, as expected. Our results challenge the utility of blood NAD+ levels as a biomarker of ageing or lifestyle factors.