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<p>Consumption of sweeteners and sweetness enhancers (S&amp;SEs) is a popular strategy to reduce sugar intake, but the role of S&amp;SEs in body weight regulation and gut microbiota composition remains debated. Here, we show that S&amp;SEs in a healthy diet support weight loss maintenance and beneficial gut microbiota shifts in adults with overweight or obesity. In this multi-centre, randomized, controlled trial, we included 341 adults and 38 children with overweight or obesity. Adults followed a 2-month low-energy diet for ≥5% weight loss, followed by a 10-month healthy ad libitum diet with &lt;10% energy from sugars. One group replaced sugar-rich products with S&amp;SE products (S&amp;SEs group), while the other did not (sugar group). Primary outcomes included changes in body weight and gut microbiota composition at 1 year. Secondary outcomes included changes in cardiometabolic parameters. The S&amp;SEs group, compared to the sugar group, maintained greater weight loss at 1 year (1.6 ± 0.7 kg, <i>P</i> = 0.029) and exhibited distinct gut microbiota shifts, with increased short-chain fatty acid and methane-producing taxa (<i>q</i> ≤ 0.05). No significant differences were observed in cardiometabolic markers or in children. Overall, our findings indicate that prolonged consumption of S&amp;SEs in a healthy diet is a safe strategy for obesity management. ClinicalTrial.gov identifier: <a href="https://clinicaltrials.gov/study/NCT04226911">NCT04226911</a>.</p>

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Effect of sweeteners and sweetness enhancers on weight management and gut microbiota composition in individuals with overweight or obesity: the SWEET study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月7日

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  • Michelle D. Pang,
  • Louise Kjølbæk,
  • Jacco J. A. J. Bastings,
  • Sabina Stoffer Hjorth Andersen,
  • Alexander Umanets,
  • Mônica Maurer Sost,
  • Santiago Navas-Carretero,
  • Kyriakos Reppas,
  • Graham Finlayson,
  • Charo E. Hodgkins,
  • Marta del Álamo,
  • Tony Lam,
  • Hariklia Moshoyiannis,
  • Edith J. M. Feskens,
  • Tanja C. M. Adam,
  • Gijs H. Goossens,
  • Jason C. G. Halford,
  • Joanne A. Harrold,
  • Yannis Manios,
  • J. Alfredo Martinez,
  • Ellen E. Blaak,
  • Anne Raben

摘要

Consumption of sweeteners and sweetness enhancers (S&SEs) is a popular strategy to reduce sugar intake, but the role of S&SEs in body weight regulation and gut microbiota composition remains debated. Here, we show that S&SEs in a healthy diet support weight loss maintenance and beneficial gut microbiota shifts in adults with overweight or obesity. In this multi-centre, randomized, controlled trial, we included 341 adults and 38 children with overweight or obesity. Adults followed a 2-month low-energy diet for ≥5% weight loss, followed by a 10-month healthy ad libitum diet with <10% energy from sugars. One group replaced sugar-rich products with S&SE products (S&SEs group), while the other did not (sugar group). Primary outcomes included changes in body weight and gut microbiota composition at 1 year. Secondary outcomes included changes in cardiometabolic parameters. The S&SEs group, compared to the sugar group, maintained greater weight loss at 1 year (1.6 ± 0.7 kg, P = 0.029) and exhibited distinct gut microbiota shifts, with increased short-chain fatty acid and methane-producing taxa (q ≤ 0.05). No significant differences were observed in cardiometabolic markers or in children. Overall, our findings indicate that prolonged consumption of S&SEs in a healthy diet is a safe strategy for obesity management. ClinicalTrial.gov identifier: NCT04226911.