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<p>Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.</p>

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A short-term, high-caloric diet has prolonged effects on brain insulin action in men

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月21日

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  • Stephanie Kullmann,
  • Lore Wagner,
  • Robert Hauffe,
  • Anne Kühnel,
  • Leontine Sandforth,
  • Ralf Veit,
  • Corinna Dannecker,
  • Jürgen Machann,
  • Andreas Fritsche,
  • Nobert Stefan,
  • Hubert Preissl,
  • Nils B. Kroemer,
  • Martin Heni,
  • André Kleinridders,
  • Andreas L. Birkenfeld

摘要

Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.