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<p>Despite transformative advances in nanoscale microscopy and spatiotemporal genomics, a coherent understanding of how transient mechanical events drive long-term tissue development or pathology remains elusive, exposing critical gaps in linking mechanical signals to their biological consequences. To address this disconnect, we survey the literature on timescales of membrane mechanosensing, cytoplasmic mechanotransduction and nuclear mechanoresponse, emphasizing mechanoadaptive strategies such as talin filtering of mechanical noise through folding–unfolding dynamics and force–lifetime-dependent molecular stabilization to gate nuclear signalling. By compiling the MechanoTemporal Atlas, we highlight several frontiers, including the role of pulsatile cellular contractions in tissue morphogenesis through molecular frequency modulation, the propagation of rapid mechanical signals across cells, and the dynamic sensing of viscoelastic tissue properties via time-gated cellular protrusions. Bridging these timescales promises to provide insights into the role of mechanobiology in health and disease.</p>

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Mechanobiology across timescales

  • 期刊论文

  • 发表日期：

    2025年10月6日

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  • Bo Cheng,
  • Moxiao Li,
  • Min Lin,
  • Hui Guo,
  • Feng Xu

摘要

Despite transformative advances in nanoscale microscopy and spatiotemporal genomics, a coherent understanding of how transient mechanical events drive long-term tissue development or pathology remains elusive, exposing critical gaps in linking mechanical signals to their biological consequences. To address this disconnect, we survey the literature on timescales of membrane mechanosensing, cytoplasmic mechanotransduction and nuclear mechanoresponse, emphasizing mechanoadaptive strategies such as talin filtering of mechanical noise through folding–unfolding dynamics and force–lifetime-dependent molecular stabilization to gate nuclear signalling. By compiling the MechanoTemporal Atlas, we highlight several frontiers, including the role of pulsatile cellular contractions in tissue morphogenesis through molecular frequency modulation, the propagation of rapid mechanical signals across cells, and the dynamic sensing of viscoelastic tissue properties via time-gated cellular protrusions. Bridging these timescales promises to provide insights into the role of mechanobiology in health and disease.