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<p>Noninvasive transcranial photoacoustic computed tomography (PACT) of the human brain, despite its clinical potential as a complementary technology to functional MRI, remains impeded by the acoustic distortion induced by the human skull. The distortion, which is attributed to the markedly different material properties of the skull relative to soft tissue, results in heavily aberrated PACT images. Herein, we report an experimental demonstration of the de-aberration of PACT images through an ex-vivo adult human skull using a homogeneous elastic model for the skull. Using only the geometry, position, and orientation of the skull, obtained from adjunct imaging data and fiducial markers, we faithfully de-aberrate the PACT images of light-absorbing phantoms acquired through an ex-vivo human skull for different levels of phantom complexity and positions. We also demonstrate the generality of our results by attaining a similar extent of de-aberration through a second ex-vivo human skull. Our work addresses the longstanding challenge of skull-induced aberrations in transcranial PACT and advances the field towards unlocking the full potential of transcranial human brain PACT.</p>

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De-aberration for noninvasive transcranial photoacoustic computed tomography through an adult human skull

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月14日

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  • Yousuf Aborahama,
  • Karteekeya Sastry,
  • Manxiu Cui,
  • Yang Zhang,
  • Yilin Luo,
  • Rui Cao,
  • Geng Ku,
  • Jigmi Basumatary,
  • Junhao Zhu,
  • Siying Kong,
  • Lihong V. Wang

摘要

Noninvasive transcranial photoacoustic computed tomography (PACT) of the human brain, despite its clinical potential as a complementary technology to functional MRI, remains impeded by the acoustic distortion induced by the human skull. The distortion, which is attributed to the markedly different material properties of the skull relative to soft tissue, results in heavily aberrated PACT images. Herein, we report an experimental demonstration of the de-aberration of PACT images through an ex-vivo adult human skull using a homogeneous elastic model for the skull. Using only the geometry, position, and orientation of the skull, obtained from adjunct imaging data and fiducial markers, we faithfully de-aberrate the PACT images of light-absorbing phantoms acquired through an ex-vivo human skull for different levels of phantom complexity and positions. We also demonstrate the generality of our results by attaining a similar extent of de-aberration through a second ex-vivo human skull. Our work addresses the longstanding challenge of skull-induced aberrations in transcranial PACT and advances the field towards unlocking the full potential of transcranial human brain PACT.