Scholarlink

<p>Endogenous metabolites from the human microbiome play a crucial role in human health and disease. Their involvement in immune and inflammatory regulatory processes both under physiological conditions and diseases renders them essential for pathological research and therapeutic development. However, the microbial metabolites that mediate interactions between the host and microbiome remain largely undefined. Here, we explored a group of ketoacyl synthases from <i>Eikenella</i> spp. that constitute the HACEK group of human opportunistic pathogens through global genome mining. In vivo and in vitro verification of these enzymes resulted in the production of three dialkylresorcinols, which were found to act as agonists of the aryl hydrocarbon receptor and reduce the inflammatory factors of multiple immune cells. These results demonstrate that human-associated <i>Eikenella</i> spp. are capable of producing bioactive aromatic polyketides, which may suggest a molecular mechanism of immunomodulation by the human microbiota.</p><p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Characterization of immunomodulatory dialkylresorcinols from the human-associated HACEK bacteria

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月18日

查看全文
  • Jiangnan Xia,
  • Juan Liang,
  • Yan Luo,
  • Yu Sun,
  • Chen Niu,
  • Tian Xu,
  • Lihan Zhang

摘要

Endogenous metabolites from the human microbiome play a crucial role in human health and disease. Their involvement in immune and inflammatory regulatory processes both under physiological conditions and diseases renders them essential for pathological research and therapeutic development. However, the microbial metabolites that mediate interactions between the host and microbiome remain largely undefined. Here, we explored a group of ketoacyl synthases from Eikenella spp. that constitute the HACEK group of human opportunistic pathogens through global genome mining. In vivo and in vitro verification of these enzymes resulted in the production of three dialkylresorcinols, which were found to act as agonists of the aryl hydrocarbon receptor and reduce the inflammatory factors of multiple immune cells. These results demonstrate that human-associated Eikenella spp. are capable of producing bioactive aromatic polyketides, which may suggest a molecular mechanism of immunomodulation by the human microbiota.