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<p>Understanding how quantum electron and nuclei motions drive biomolecular reactions is a foundational challenge in quantum chemistry and biology. While ultrafast charge migration in DNA is theorized to influence genome stability and signaling, real-time observation remains elusive. Here, we report a theoretical study employing high-level ab initio simulations to reveal attosecond charge dynamics and electronic coherences within canonical DNA base pairs. Experimentally, we propose the “quantum attomicroscope” (Q-attomicroscope)—a conceptual instrument providing attosecond temporal and sub-angstrom spatial resolution. By bridging theory and instrumentation, this work outlines a pathway for laser-mediated DNA manipulation with transformative implications for chemical reactivity and personalized medicine.</p><p></p>

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Imaging quantum chemistry in action with quantum attomicroscopy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月27日

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  • Nikolay V. Golubev,
  • Mohammed Th. Hassan

摘要

Understanding how quantum electron and nuclei motions drive biomolecular reactions is a foundational challenge in quantum chemistry and biology. While ultrafast charge migration in DNA is theorized to influence genome stability and signaling, real-time observation remains elusive. Here, we report a theoretical study employing high-level ab initio simulations to reveal attosecond charge dynamics and electronic coherences within canonical DNA base pairs. Experimentally, we propose the “quantum attomicroscope” (Q-attomicroscope)—a conceptual instrument providing attosecond temporal and sub-angstrom spatial resolution. By bridging theory and instrumentation, this work outlines a pathway for laser-mediated DNA manipulation with transformative implications for chemical reactivity and personalized medicine.