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<p>Proteins are central to nearly all biological processes; their functions are tightly regulated by dynamic mechanisms such as covalent alterations; e.g., post-translational modifications (PTMs). These modifications can influence the protein’s structure, localization, and activity. Inspired by this diversity and regulation, advances in synthetic organic chemistry have enabled the production of a plethora of novel proteins for both basic research and biomedical applications. Recent progress in structural elucidation technologies and modern organic chemistry has enabled atom-level modifications, significantly enhancing our ability to tailor protein function. These approaches greatly expand the toolkit currently available for generating complex proteins with unique structural and functional properties. In this review, we summarize recent progress in chemical protein engineering and highlight its emerging applications in catalysis, functional studies, and drug development.</p><p></p>

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Advancing protein engineering via organic chemistry

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月18日

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  • Raj V. Nithun,
  • Manjeet Singh,
  • Adam Baransi,
  • Muhammad Jbara

摘要

Proteins are central to nearly all biological processes; their functions are tightly regulated by dynamic mechanisms such as covalent alterations; e.g., post-translational modifications (PTMs). These modifications can influence the protein’s structure, localization, and activity. Inspired by this diversity and regulation, advances in synthetic organic chemistry have enabled the production of a plethora of novel proteins for both basic research and biomedical applications. Recent progress in structural elucidation technologies and modern organic chemistry has enabled atom-level modifications, significantly enhancing our ability to tailor protein function. These approaches greatly expand the toolkit currently available for generating complex proteins with unique structural and functional properties. In this review, we summarize recent progress in chemical protein engineering and highlight its emerging applications in catalysis, functional studies, and drug development.