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<p>Deuterated alcohols are valuable synthetic targets due to their roles in pharmaceuticals, materials, and mechanistic studies. Conventional homogeneous strategies for their synthesis, while effective, often require expensive ligands and offer limited catalyst recovery. Heterogeneous catalysis, by contrast, provides a robust and recyclable alternative with enhanced scalability. Recent advances in supported metal nanoparticles and single-atom catalysts (SACs) have enabled high-efficiency and site-selective deuteration of alcohols. This Perspective presents heterogeneous catalytic systems as evolving into scalable and efficient platforms for deuterated alcohol synthesis, opening new directions for sustainable isotope incorporation.</p>

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Supported nanoparticles and single-atom catalysts for the synthesis of deuterated alcohols

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月28日

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  • Jing-Jing Tang,
  • Shu-Xian Li,
  • Wen-Xin Zhou,
  • Xiang-Ting Min,
  • Botao Qiao

摘要

Deuterated alcohols are valuable synthetic targets due to their roles in pharmaceuticals, materials, and mechanistic studies. Conventional homogeneous strategies for their synthesis, while effective, often require expensive ligands and offer limited catalyst recovery. Heterogeneous catalysis, by contrast, provides a robust and recyclable alternative with enhanced scalability. Recent advances in supported metal nanoparticles and single-atom catalysts (SACs) have enabled high-efficiency and site-selective deuteration of alcohols. This Perspective presents heterogeneous catalytic systems as evolving into scalable and efficient platforms for deuterated alcohol synthesis, opening new directions for sustainable isotope incorporation.