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<p>Mechanically interlocked molecules (MIMs) such as rotaxanes and catenanes attract significant interest due to their unique structures and dynamic properties. Cyclodextrin-based rotaxanes (CD-rotaxanes) have emerged as promising supramolecular systems for biological and medicinal applications. Their host-guest interactions and mechanical bonds provide enhanced stability, stimuli-responsiveness, and tunable functionality. This review highlights their roles in targeted therapy, controlling drug release, theranostic agents, enzyme inhibitor, gene transport and bioimaging. Challenges and future perspectives in translating CD-rotaxanes to biomedical applications are discussed, emphasizing their potential as a next-generation therapeutic platform.</p>

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Cyclodextrin-based rotaxanes as a versatile platform for biological and medicinal applications

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月14日

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  • Sapir Paryente,
  • Hajar Aledwan,
  • Abed Saady

摘要

Mechanically interlocked molecules (MIMs) such as rotaxanes and catenanes attract significant interest due to their unique structures and dynamic properties. Cyclodextrin-based rotaxanes (CD-rotaxanes) have emerged as promising supramolecular systems for biological and medicinal applications. Their host-guest interactions and mechanical bonds provide enhanced stability, stimuli-responsiveness, and tunable functionality. This review highlights their roles in targeted therapy, controlling drug release, theranostic agents, enzyme inhibitor, gene transport and bioimaging. Challenges and future perspectives in translating CD-rotaxanes to biomedical applications are discussed, emphasizing their potential as a next-generation therapeutic platform.