Scholarlink

<p>The extreme and heterogeneous Qinghai-Tibet Plateau challenges wildlife survival. Przewalski’s gazelle (<i>Procapra przewalskii</i>) is confined to the northeastern Plateau around Qinghai Lake, where habitat fragmentation exposes isolated populations to distinct plant resources. How this species adapts to dietary heterogeneity via internal physiology remains unclear. Here, we integrated dietary analysis, shotgun metagenomics, and untargeted metabolomics to examine relationships among diet, gut microbiome function, and metabolic outputs across three regions. We observed population-specific differences in plant consumption, gut microbial composition, and functional potential, notably in carbohydrate degradation, plant secondary metabolite transformation, and energy metabolism. Metabolomics revealed shifts in short-chain fatty acids and lipid- and energy-related pathways. Co-occurrence networks and partial least squares path modeling (PLS-PM) indicated diet influences metabolites indirectly via the gut microbiome as a key mediator. Our findings establish a “diet–gut microbiome–metabolic output” framework, highlighting microbial mechanisms underpinning local adaptation and informing conservation of endangered plateau species.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Gut microbiota mediates dietary adaptation across spatially varying diets in the endangered Przewalski’s gazelle (Procapra przewalskii)

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月20日

查看全文
  • Fan Guo,
  • Bin Li,
  • Pengfei Song,
  • Meng Zhang,
  • Tianshi Hu,
  • Zhongyuan Lin,
  • Hongmei Gao,
  • Chengbo Liang,
  • Tongzuo Zhang,
  • Zhenyuan Cai

摘要

The extreme and heterogeneous Qinghai-Tibet Plateau challenges wildlife survival. Przewalski’s gazelle (Procapra przewalskii) is confined to the northeastern Plateau around Qinghai Lake, where habitat fragmentation exposes isolated populations to distinct plant resources. How this species adapts to dietary heterogeneity via internal physiology remains unclear. Here, we integrated dietary analysis, shotgun metagenomics, and untargeted metabolomics to examine relationships among diet, gut microbiome function, and metabolic outputs across three regions. We observed population-specific differences in plant consumption, gut microbial composition, and functional potential, notably in carbohydrate degradation, plant secondary metabolite transformation, and energy metabolism. Metabolomics revealed shifts in short-chain fatty acids and lipid- and energy-related pathways. Co-occurrence networks and partial least squares path modeling (PLS-PM) indicated diet influences metabolites indirectly via the gut microbiome as a key mediator. Our findings establish a “diet–gut microbiome–metabolic output” framework, highlighting microbial mechanisms underpinning local adaptation and informing conservation of endangered plateau species.