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<p>How environmental variation shapes the human cerebral cortex remains incompletely understood. Here we compare cortical <i>brainprints</i> – individual profiles of regional cortical morphology – in 210 twins (age 16-78 years) to distinguish prenatal, adult naturalistic and experimentally induced environmental variation from genetic contributions. Monozygotic twins showed higher brainprint similarity than dizygotic twins, consistent with genetic effects. Lasting influences of early environment were evident in lower brainprint similarity in monozygotic twin-pairs with greater birthweight discordances, driven by surface area across the cortical ribbon. In contrast, within-pair differences in adult weight and lifestyle had minimal influence. Still, a 10-week virtual-reality navigation intervention revealed training-induced changes in the gray-white interface, with curvature and area changes supported by microstructural reconfigurations. Relative brainprint similarity increased in monozygotic but diverged in dizygotic pairs following training. These findings show that distinct environmental influences acting at prenatal and adult stages are reflected in different features of the human cerebral cortex.</p>

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Feature-specific environmental contributions to human cortical architecture revealed by twin brainprints

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月20日

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  • Kristine B. Walhovd,
  • Anne Cecilie Sjøli Bråthen,
  • Knut Overbye,
  • Jonas Kransberg,
  • Øystein Sørensen,
  • Pablo F. Garrido,
  • Inge K. Amlien,
  • Jose-Luis Alatorre-Warren,
  • Athanasia M. Mowinckel,
  • Maksim Slivka,
  • Nikolai O. Czajkowski,
  • Yunpeng Wang,
  • Paulina Due-Tønnessen,
  • Jennifer R. Harris,
  • Martin Lövdén,
  • Didac Vidal-Pineiro,
  • Lars Nyberg,
  • Anders M. Fjell,
  • Markus H. Sneve

摘要

How environmental variation shapes the human cerebral cortex remains incompletely understood. Here we compare cortical brainprints – individual profiles of regional cortical morphology – in 210 twins (age 16-78 years) to distinguish prenatal, adult naturalistic and experimentally induced environmental variation from genetic contributions. Monozygotic twins showed higher brainprint similarity than dizygotic twins, consistent with genetic effects. Lasting influences of early environment were evident in lower brainprint similarity in monozygotic twin-pairs with greater birthweight discordances, driven by surface area across the cortical ribbon. In contrast, within-pair differences in adult weight and lifestyle had minimal influence. Still, a 10-week virtual-reality navigation intervention revealed training-induced changes in the gray-white interface, with curvature and area changes supported by microstructural reconfigurations. Relative brainprint similarity increased in monozygotic but diverged in dizygotic pairs following training. These findings show that distinct environmental influences acting at prenatal and adult stages are reflected in different features of the human cerebral cortex.