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<p>Tartrazine, along with many other absorbing molecules, has recently emerged as a promising tissue-clearing agent for achieving transient and reversible optical transparency in live animals. In this mini-review, we describe the fundamental physical origins of tissue opacity, extract engineering principles guiding the design of next-generation dye-based clearing agents, and summarize recent advances in dye-enabled in vivo tissue clearing. We also discuss current challenges and offer forward-looking perspectives to inform future research.</p>

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In vivo tissue clearing with tartrazine and other dye molecules

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月3日

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  • Victoria Crunkleton,
  • Guosong Hong

摘要

Tartrazine, along with many other absorbing molecules, has recently emerged as a promising tissue-clearing agent for achieving transient and reversible optical transparency in live animals. In this mini-review, we describe the fundamental physical origins of tissue opacity, extract engineering principles guiding the design of next-generation dye-based clearing agents, and summarize recent advances in dye-enabled in vivo tissue clearing. We also discuss current challenges and offer forward-looking perspectives to inform future research.