Scholarlink

<p>Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) has emerged as a significant public health concern. The biofilm formation capability of MRSA is often associated with high levels of antimicrobial resistance. Therefore, the development of novel therapeutic strategies to combat MRSA is urgently warranted. By drug repurposing, resorantel, originally developed as an antiparasitic agent, has demonstrated significantly bactericidal activity against MRSA and its biofilms with effectively inhibitory activity against the emergence of drug resistance. Furthermore, resorantel displayed significant in vivo antibacterial efficacy in both topic and systemic infection models. Mechanistic investigations employing transcriptomics, fluorescent probes, molecular dynamics simulations, and surface plasmon resonance analysis revealed that proton motive force and MurB are likely the potential targets of resorantel. Collectively, this study identifies resorantel as a promising novel antimicrobial agent with potential for use in the treatment of MRSA and its biofilm-related infections.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Resorantel: a dual-targeting therapeutic with potent efficacy against Staphylococcus aureus with low potential for drug resistance

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月2日

查看全文
  • Pengfei She,
  • Shaowei Guo,
  • Dan Xiao,
  • Guanqing Huang,
  • Yiqing Liu,
  • Mengna Li,
  • Lihua Lu,
  • Yelan Hong,
  • Yong Wu

摘要

Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a significant public health concern. The biofilm formation capability of MRSA is often associated with high levels of antimicrobial resistance. Therefore, the development of novel therapeutic strategies to combat MRSA is urgently warranted. By drug repurposing, resorantel, originally developed as an antiparasitic agent, has demonstrated significantly bactericidal activity against MRSA and its biofilms with effectively inhibitory activity against the emergence of drug resistance. Furthermore, resorantel displayed significant in vivo antibacterial efficacy in both topic and systemic infection models. Mechanistic investigations employing transcriptomics, fluorescent probes, molecular dynamics simulations, and surface plasmon resonance analysis revealed that proton motive force and MurB are likely the potential targets of resorantel. Collectively, this study identifies resorantel as a promising novel antimicrobial agent with potential for use in the treatment of MRSA and its biofilm-related infections.