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<p>Somatic gene mutations (SGMs) that drive clonal haematopoiesis (CH) have been shown to be more prevalent in people with HIV (PWH), potentially contributing to the higher risk of comorbidities in PWH compared to those without HIV. It is unknown whether mosaic chromosomal alterations (mCA), another form of CH, are associated with HIV. We demonstrate, for the first time, a markedly lower prevalence of mosaic chromosomal alterations (mCA), particularly loss of chromosome Y, in PWH compared to participants without HIV - an opposing pattern to SGMs. Our findings that mCA development may be suppressed in HIV infection suggest that the selective pressures driving mCA-related CH differ fundamentally from those driving SGM-related CH.</p>

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Mosaic chromosomal alterations are suppressed in older adults with HIV

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月21日

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  • Kiarash Behrouzfar,
  • Win Min Han,
  • Rashindrie Perera,
  • Jason Li,
  • Katherine E. Scull,
  • Kerryn Howlett,
  • Mark Bloch,
  • David A. Baker,
  • Beng Eu,
  • Ellen Bowden-Reid,
  • Don E. Smith,
  • Jennifer F. Hoy,
  • Ian Woolley,
  • Robert Finlayson,
  • David J. Templeton,
  • Gail V. Matthews,
  • Jane Costello,
  • Mark A. Dawson,
  • Sarah-Jane Dawson,
  • Mark N. Polizzotto,
  • Kathy Petoumenos,
  • Nila J. Dharan,
  • Paul Yeh,
  • Kiarash Behrouzfar,
  • Win M. Han,
  • Rashindrie Perera,
  • Jason Li,
  • Katherine E. Scull,
  • Kerryn Howlett,
  • Mark Bloch,
  • Trina Vincent,
  • David A. Baker,
  • Beng Eu,
  • Helen Lau,
  • Ellen Bowden-Reid,
  • Don E. Smith,
  • Kathryn Acklom,
  • Jennifer F. Hoy,
  • Sally Price,
  • Ian Woolley,
  • Jessica O’Bryan,
  • Robert Finlayson,
  • David J. Templeton,
  • Brett Sinclair,
  • Gail V. Matthews,
  • Jane Costello,
  • Mark A. Dawson,
  • Sarah-Jane Dawson,
  • Mark N. Polizzotto,
  • Kathy Petoumenos,
  • Nila J. Dharan,
  • Paul Yeh

摘要

Somatic gene mutations (SGMs) that drive clonal haematopoiesis (CH) have been shown to be more prevalent in people with HIV (PWH), potentially contributing to the higher risk of comorbidities in PWH compared to those without HIV. It is unknown whether mosaic chromosomal alterations (mCA), another form of CH, are associated with HIV. We demonstrate, for the first time, a markedly lower prevalence of mosaic chromosomal alterations (mCA), particularly loss of chromosome Y, in PWH compared to participants without HIV - an opposing pattern to SGMs. Our findings that mCA development may be suppressed in HIV infection suggest that the selective pressures driving mCA-related CH differ fundamentally from those driving SGM-related CH.