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<p>Placebo analgesia is widely believed to rely on psychological, genetic, and biological factors. Whilst these factors have been assessed in single expressions of this phenomenon, few have documented its consistency over time, limiting understanding of its stability, and by extension, consideration in non-experimental settings. Here we show in 30 control participants by combining magnetic resonance imaging and a longitudinal design spanning five sessions, the psychological and neural substrates underpinning Placebo Analgesia response consistency.</p>

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Placebo analgesia persistence: evaluating behavioural stability in repeated trials

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月28日

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  • Lewis S. Crawford,
  • Damien C. Boorman,
  • Ashleigh H. Wake,
  • Allan Peng,
  • Rebecca V. Robertson,
  • James W. M. Kang,
  • Furby Robson,
  • Paul M. Macey,
  • Kevin A. Keay,
  • Luke A. Henderson

摘要

Placebo analgesia is widely believed to rely on psychological, genetic, and biological factors. Whilst these factors have been assessed in single expressions of this phenomenon, few have documented its consistency over time, limiting understanding of its stability, and by extension, consideration in non-experimental settings. Here we show in 30 control participants by combining magnetic resonance imaging and a longitudinal design spanning five sessions, the psychological and neural substrates underpinning Placebo Analgesia response consistency.