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<p>A key step in gene expression is the opening of DNA at the transcription start site (TSS), allowing RNA polymerase to begin RNA synthesis. In eukaryotes, RNA polymerase II initiates transcription within the pre-initiation complex (PIC), which includes TFIIH. The XPB subunit of TFIIH drives DNA unwinding at the TSS through ATP-dependent activity. However, some promoters enable transcription without XPB, likely due to intrinsically unstable DNA that does not require active unwinding. This mechanism may reflect an evolutionary remnant of archaeal transcription.</p>

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RNA polymerase II transcription initiation with and without XPB translocase activity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月7日

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  • Mario Zurita,
  • Samantha Cruz-Ruiz,
  • Eduardo Calvario

摘要

A key step in gene expression is the opening of DNA at the transcription start site (TSS), allowing RNA polymerase to begin RNA synthesis. In eukaryotes, RNA polymerase II initiates transcription within the pre-initiation complex (PIC), which includes TFIIH. The XPB subunit of TFIIH drives DNA unwinding at the TSS through ATP-dependent activity. However, some promoters enable transcription without XPB, likely due to intrinsically unstable DNA that does not require active unwinding. This mechanism may reflect an evolutionary remnant of archaeal transcription.