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<p>Intercellular bridges (ICBs) are fundamental and evolutionarily conserved structures in spermatogenesis, with roles that extend far beyond simple cytoplasmic connections. These stable conduits, which connect synchronously developing germ cells, are crucial for cytoplasmic sharing and intercellular communication. This review highlights the core regulatory machinery governing ICBs dynamics, including their formation and function, in mouse and <i>Drosophila melanogaster</i>. It further explores the distribution patterns of ICBs and their molecular components across various animal species. Lastly, it identifies key challenges and future directions necessary to fully elucidate the regulatory mechanisms and broader biological significance of ICBs in male germ cell development.</p>

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The formation and function of intercellular bridges in male germlines

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月27日

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  • Jian Cui,
  • Jiaxuan Cheng,
  • Bingbing Wu,
  • Andong He

摘要

Intercellular bridges (ICBs) are fundamental and evolutionarily conserved structures in spermatogenesis, with roles that extend far beyond simple cytoplasmic connections. These stable conduits, which connect synchronously developing germ cells, are crucial for cytoplasmic sharing and intercellular communication. This review highlights the core regulatory machinery governing ICBs dynamics, including their formation and function, in mouse and Drosophila melanogaster. It further explores the distribution patterns of ICBs and their molecular components across various animal species. Lastly, it identifies key challenges and future directions necessary to fully elucidate the regulatory mechanisms and broader biological significance of ICBs in male germ cell development.